Wedlolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
文献类型：期刊论文
| 作者 | M Kobori ; I Yang ; Gong DH(龚登凰) ; V Heissmeyer ; H Zhu ; Y-K Jung ; M Angelica ; M Gakidis ; A Rao ; T Sekine ; F Ikegami ; Yuan CY(袁承业) ; Yuan JY(袁钧瑛) |
| 刊名 | Cell Death Differ.
 |
| 出版日期 | 2004 |
| 卷号 | 11期号:1页码:123-130 |
| 其他题名 | 蟛蜞菊内酯通过直接抑制IKK复合物影响 LPS-诱导的caspase-11的表达 |
| 通讯作者 | 袁钧瑛 |
| 英文摘要 | Caspase-11 is a key regulator of proinflammatory cytokine IL-1 βmaturation and pathological apptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulaion such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natual compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-kB-mediated trascription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critlcal for activation of NF-kB by mediating phosphorylation and degradation of LkBα |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1038/sj.cdd.4401325 |
| 语种 | 英语 |
| 公开日期 | 2013-01-09 |
| 源URL | [http://202.127.28.38/handle/331003/11046]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | M Kobori,I Yang,Gong DH,et al. Wedlolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex[J]. Cell Death Differ.,2004,11(1):123-130. |
| APA | M Kobori.,I Yang.,Gong DH.,V Heissmeyer.,H Zhu.,...&Yuan JY.(2004).Wedlolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex.Cell Death Differ.,11(1),123-130. |
| MLA | M Kobori,et al."Wedlolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex".Cell Death Differ. 11.1(2004):123-130. |
入库方式： OAI收割
来源：上海有机化学研究所
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