Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies
文献类型：期刊论文
| 作者 | Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业) |
| 刊名 | MedChemComm
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:4页码:315-320 |
| 其他题名 | 基于二苯基丁基哌啶结构的细胞自吞噬诱导剂: 合成与构效关系研究 |
| 英文摘要 | A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure-activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF(3) group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1039/c0md00236d |
| 语种 | 英语 |
| WOS记录号 | WOS:000290697800012 |
| 公开日期 | 2013-01-09 |
| 源URL | [http://202.127.28.38/handle/331003/11088]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Chen G,Xia HG,Cai Y,et al. Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies[J]. MedChemComm,2011,2(4):315-320. |
| APA | Chen G,Xia HG,Cai Y,Ma DW,Yuan JY,&Yuan CY.(2011).Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies.MedChemComm,2(4),315-320. |
| MLA | Chen G,et al."Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies".MedChemComm 2.4(2011):315-320. |
入库方式： OAI收割
来源：上海有机化学研究所
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