Purification, characterization and structural study of the neuro-peptides from scorpion Buthus martensi karsch
文献类型：期刊论文
| 作者 | Wu HM(吴厚铭) ; Wu G(吴宫) ; Huang XL(黄晓琳) ; He FH(何发虎) ; Jiang SK(江绍开) |
| 刊名 | Pure Appl. Chem.
 |
| 出版日期 | 1999 |
| 卷号 | 71期号:6页码:1157-1162 |
| ISSN号 | 0033-4545 |
| 其他题名 | 马氏钳蝎神经肽的纯化、特性和结构研究 |
| 通讯作者 | 吴厚铭 |
| 英文摘要 | Total 40 peptides were purified from the venom of B. Martensi Karsch, and characterized on the basis of their molecular weight (ESI-MS), N-terminal sequence (5 residues) and the toxicity to mammals and insects. Among 29 long chain peptides (60-70 residues) a novel anti-insect toxin BmKα-IT1 and a new anti-mammal toxin BmK IV were identified and their primary structures were determined by Edman degradation. Besides, from 11 short chain peptides (28-40 residues), three K^+ channel inhibitors were identified and their action modes were investigated by the assay in acutely dissociated rat hippocampal neurons using whole-cell patch-clamp configuration. The solution structure of BmK I, the main toxin, was determined by 2D ^1-NMR spectroscopy and molecular modeling techniques. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1351/pac199971061157 |
| 语种 | 英语 |
| WOS记录号 | WOS:000082878200038 |
| 公开日期 | 2013-02-21 |
| 源URL | [http://202.127.28.38/handle/331003/17241]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Wu HM,Wu G,Huang XL,et al. Purification, characterization and structural study of the neuro-peptides from scorpion Buthus martensi karsch[J]. Pure Appl. Chem.,1999,71(6):1157-1162. |
| APA | 吴厚铭,吴宫,黄晓琳,何发虎,&江绍开.(1999).Purification, characterization and structural study of the neuro-peptides from scorpion Buthus martensi karsch.Pure Appl. Chem.,71(6),1157-1162. |
| MLA | 吴厚铭,et al."Purification, characterization and structural study of the neuro-peptides from scorpion Buthus martensi karsch".Pure Appl. Chem. 71.6(1999):1157-1162. |
入库方式： OAI收割
来源：上海有机化学研究所
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