Solution structure and dynamics of human metallothionein-3 (MT-3) zinc
文献类型：期刊论文
| 作者 | Wang H(王辉) ; Zhang Q(张琪) ; Cai B(蔡斌) ; Li HY(李红燕) ; Kong-Hung Sze ; Huang ZX(黄仲贤) ; Wu HM(吴厚铭) ; SUN HONGZHE |
| 刊名 | FEBS Lett.
 |
| 出版日期 | 2006 |
| 卷号 | 580期号:3页码:795-800 |
| ISSN号 | 0014-5793 |
| 其他题名 | 人金属硫蛋白 MT3的溶液结构和动力学 |
| 通讯作者 | 吴厚铭 ; SUN HONGZHE |
| 英文摘要 | Alzheimer's disease is characterized by progressive loss of neurons accompanied by the formation of intraneural neurofibrillary tangles and extracellular amyloid plaques. Human neuronal growth inhibitory factor, classified as metallothionein-3 (MT-3), was found to be related to the neurotrophic activity promoting cortical neuron survival and dendrite outgrowth in the cell culture studies. We have determined the solution structure of the a-domain of human MT-3 (residues 32-68) by multinuclear and multidimensional NMR spectroscopy in combination with the molecular dynamic simulated annealing approach. The human MT-3 shows two metal-thiolate clusters, one in the N-terminus (beta-domain) and one in the C-terminus (alpha-domain). The overall fold of the alpha-domain is similar to that of mouse MT-3. However, human MT-3 has a longer loop in the acidic hexapeptide insertion than that of mouse MT-3. Surprisingly, the backbone dynamics of the protein revealed that the beta-domain exhibits similar internal motion to the alpha-domain, although the N-terminal residues are more flexible. Our results may provide useful information for understanding the structure-function relationship of human MT-3. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.fcbsiet.2005.12.099 |
| 语种 | 英语 |
| 公开日期 | 2013-02-21 |
| 源URL | [http://202.127.28.38/handle/331003/17373]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Wang H,Zhang Q,Cai B,et al. Solution structure and dynamics of human metallothionein-3 (MT-3) zinc[J]. FEBS Lett.,2006,580(3):795-800. |
| APA | 王辉.,张琪.,蔡斌.,李红燕.,Kong-Hung Sze.,...&SUN HONGZHE.(2006).Solution structure and dynamics of human metallothionein-3 (MT-3) zinc.FEBS Lett.,580(3),795-800. |
| MLA | 王辉,et al."Solution structure and dynamics of human metallothionein-3 (MT-3) zinc".FEBS Lett. 580.3(2006):795-800. |
入库方式： OAI收割
来源：上海有机化学研究所
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