Robustness and dissipation of mitogen-activated protein kinases signal transduction network: Underlying funneled landscape against stochastic fluctuations
文献类型：期刊论文
| 作者 | Wang J ; Zhang K ; Wang E |
| 刊名 | journal of chemical physics
 |
| 出版日期 | 2008 |
| 卷号 | 129期号:13页码:文献编号：135101 |
| 关键词 | YEAST-CELL-CYCLE GENE-EXPRESSION ENERGY LANDSCAPE INTRINSIC NOISE STABILITY DYNAMICS ULTRASENSITIVITY OSCILLATIONS LEADS COST |
| ISSN号 | 0021-9606 |
| 通讯作者 | wang j |
| 中文摘要 | we uncovered the underlying energy landscape of the mitogen-activated protein kinases signal transduction cellular network by exploring the statistical natures of the brownian dynamical trajectories. we introduce a dimensionless quantity: the robustness ratio of energy gap versus local roughness to measure the global topography of the underlying landscape. a high robustness ratio implies funneled landscape. the landscape is quite robust against environmental fluctuations and variants of the intrinsic chemical reaction rates. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259876700054 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10411]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang J,Zhang K,Wang E. Robustness and dissipation of mitogen-activated protein kinases signal transduction network: Underlying funneled landscape against stochastic fluctuations[J]. journal of chemical physics,2008,129(13):文献编号：135101. |
| APA | Wang J,Zhang K,&Wang E.(2008).Robustness and dissipation of mitogen-activated protein kinases signal transduction network: Underlying funneled landscape against stochastic fluctuations.journal of chemical physics,129(13),文献编号：135101. |
| MLA | Wang J,et al."Robustness and dissipation of mitogen-activated protein kinases signal transduction network: Underlying funneled landscape against stochastic fluctuations".journal of chemical physics 129.13(2008):文献编号：135101. |
入库方式： OAI收割
来源：长春应用化学研究所
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