光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成
文献类型：期刊论文
| 作者 | 蔡祖恽 ; 倪元 ; 张量 |
| 刊名 | 化学学报
 |
| 出版日期 | 1993 |
| 卷号 | 51期号:6页码:607-611 |
| ISSN号 | 0567-7351 |
| 其他题名 | THE SYNTHESIS OF (+)-3-METHOXY-7-ALPHA-METHYL-17-ALPHA-CYANOMETHYL-17-BETA-HYDROXY-1,3,5( 10)-ESTRATRIENE |
| 通讯作者 | 蔡祖恽 |
| 英文摘要 | The titled compound 12 was obtained through seven steps using the compound 3 as starting material. Hydrogenated compound 4 obtained from 8 was cyclized with H2SO4 to the compound 6, hydrogenation of which gave a mixture of the compound 7 and 8. The compound 8 was also secured directly by reduction of 6 with Li and liq. NH3. Deprotection of the compound 8 by HCl gave the compound 9 which was oxidized to the compound 10. Introducing the methylene group by dimethyl oxosulfonium methylide at 17-ketone in the compound 10 gave the epoxide 11 which was cleavaged to the titled compound 12 by NaCN. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 语种 | 中文 |
| 公开日期 | 2013-08-12 |
| 源URL | [http://202.127.28.38/handle/331003/27307]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | 蔡祖恽,倪元,张量. 光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成[J]. 化学学报,1993,51(6):607-611. |
| APA | 蔡祖恽,倪元,&张量.(1993).光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成.化学学报,51(6),607-611. |
| MLA | 蔡祖恽,et al."光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成".化学学报 51.6(1993):607-611. |
入库方式： OAI收割
来源：上海有机化学研究所
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