Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.
文献类型：期刊论文
| 作者 | Wu YL(吴毓林) ; Chen HB(陈海宝) ; Jiang K(蒋昆) ; Li Y(李英) ; Shan F(山峰) ; Wang DY(王东业) ; Wang YF(王燕芳) ; Wu WM(吴文敏) ; Wu YK(伍贻康) ; Yao ZJ(姚祝军) ; Le ZY(乐征宇) ; Zhou CM(周澄明) |
| 刊名 | Pure Appl. Chem.
 |
| 出版日期 | 1999 |
| 卷号 | 71期号:6页码:1139-1142 |
| ISSN号 | 0033-4545 |
| 其他题名 | 亚铁离存在下青蒿素及其衍生物分子的作用－抗疟机制探讨 |
| 通讯作者 | 吴毓林 |
| 英文摘要 | Qinghaosu(artemisinin) is the antimalarial principle of the Chinese traditional herb qinghao (Artemisia annua L.). Now qinghaosu and its derivatives have distinguished themselaves as a new generation of antimalarial drugs, especially in the treatment of multidrug-resistant cases. Qinghaosu has a unique carbon framework containing a special endoperoxy dridge, which is entirely different from that of all previous antimalarial agents and hence makes a novel antimalarial mechanism possible. Up to now there is still no clear picture about this mechanism at the molecular lever. However, the ferric/ferrous ions that are abundant in the red cell in which the parasite lives, is likely the most important co-factor for the antimalarial process of qinghaosu (scheme 1). |
| 学科主题 | 有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1351/pac199971061139 |
| 语种 | 英语 |
| 公开日期 | 2013-01-17 |
| 源URL | [http://202.127.28.38/handle/331003/13946]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wu YL,Chen HB,Jiang K,et al. Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.[J]. Pure Appl. Chem.,1999,71(6):1139-1142. |
| APA | 吴毓林.,陈海宝.,蒋昆.,李英.,山峰.,...&周澄明.(1999).Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism..Pure Appl. Chem.,71(6),1139-1142. |
| MLA | 吴毓林,et al."Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.".Pure Appl. Chem. 71.6(1999):1139-1142. |
入库方式： OAI收割
来源：上海有机化学研究所
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