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Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
文献类型：期刊论文
| 作者 | Xia YF(夏贻丰) ; 叶BUQING ; Wang, JG ; He, XJ ; Lin XF(林宪峰) ; Yao XS(姚新生) ; Ma DW(马大为) ; Slungaard, A ; Hebbel, RP ; Key, NS ; Geng JG(耿建国) |
| 刊名 | J. Immunol.
 |
| 出版日期 | 2004 |
| 卷号 | 173期号:6页码:4207-4217 |
| ISSN号 | 0022-1767 |
| 其他题名 | Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50 |
| 通讯作者 | 夏贻丰 ; 叶BUQING ; 耿建国 |
| 英文摘要 | NF-kappaB is a central transcriptional factor and a pleiotropic regulator of many genes involved in immunological responses. During the screening of a plant extract library of traditional Chinese herbal medicines, we found that NF-kappaB activity was potently inhibited by andrographolide (Andro), an abundant component of the plant Andrographis that has been commonly used as a folk remedy for alleviation of inflammatory disorders in Asia for millennia. Mechanistically, it formed a covalent adduct with reduced cysteine (62) of p50, thus blocking the binding of NF-kappaB oligonucleotide to nuclear proteins. Andro suppressed the activation of NF-kappaB in stimulated endothelial cells, which reduced the expression of cell adhesion molecule E-selectin and prevented E-selectin-mediated leukocyte adhesion under flow. It also abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo. Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223878000073 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15453]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xia YF,叶BUQING,Wang, JG,et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50[J]. J. Immunol.,2004,173(6):4207-4217. |
| APA | 夏贻丰.,叶BUQING.,Wang, JG.,He, XJ.,林宪峰.,...&耿建国.(2004).Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.J. Immunol.,173(6),4207-4217. |
| MLA | 夏贻丰,et al."Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50".J. Immunol. 173.6(2004):4207-4217. |
入库方式： OAI收割
来源：上海有机化学研究所
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