Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides
文献类型：期刊论文
| 作者 | Grauer, Andreas ; Spaeth, Andreas ; Ma DW(马大为) ; Koenig, Burkhard |
| 刊名 | Chem.-Asian J.
 |
| 出版日期 | 2009 |
| 卷号 | 4期号:7页码:1134-1140 |
| ISSN号 | 1861-4728 |
| 其他题名 | 金属催化的C-alpha-四取代氨基酸的衍生化及在环肽合成中的应用 |
| 通讯作者 | Koenig, Burkhard |
| 英文摘要 | C-alpha-tetrasubstituted amino acids are important building blocks in the design and preparation of novel peptidomimetics. We report on the functionalization of the C-alpha-tetrasubstituted THF amino acid rac-5 by copper(I) catalyzed N-arylation reactions. The aryl bromide substituent of rac-5 is replaced by a variety of aliphatic and aromatic amines. Intramolecular N-arylation yielded only small amounts of a cyclic tripeptide 2, whereas cyclic tripeptide ethers 4 and 50 were obtained in an enantiomerically pure form from a palladium(0)-catalyzed intramolecular O-arylation. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/asia.200900033 |
| 语种 | 英语 |
| WOS记录号 | WOS:000267893100016 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15601]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Grauer, Andreas,Spaeth, Andreas,Ma DW,et al. Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides[J]. Chem.-Asian J.,2009,4(7):1134-1140. |
| APA | Grauer, Andreas,Spaeth, Andreas,马大为,&Koenig, Burkhard.(2009).Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides.Chem.-Asian J.,4(7),1134-1140. |
| MLA | Grauer, Andreas,et al."Metal-Catalyzed Derivatization of C-alpha-Tetrasubstituted Amino Acids and Their Use in the Synthesis of Cyclic Peptides".Chem.-Asian J. 4.7(2009):1134-1140. |
入库方式： OAI收割
来源：上海有机化学研究所
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