Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy
文献类型：期刊论文
| 作者 | Shen, Shensi ; Zhang PT(张澎涛) ; Lovchik, Martin A. ; Li, Ying ; Tang, Liuya ; Chen, Zhimin ; Zeng, Rong ; Ma DW(马大为) ; Yuan JY(袁钧英) ; Yu Q(俞强) |
| 刊名 | J. Cell Biol.
 |
| 出版日期 | 2009 |
| 卷号 | 185期号:4页码:629-639 |
| ISSN号 | 0021-9525 |
| 其他题名 | 环酯肽毒素通过分子伴侣介导的自吞噬作用促进Hsp90事件蛋白降解 |
| 通讯作者 | 马大为 ; 袁钧英 ; 俞强 |
| 英文摘要 | Promoting the degradation of Hsp90 client proteins by inhibiting Hsp90, an important protein chaperone, has been shown to be a promising new anticancer strategy. In this study, we show that an oxazoline analogue of apratoxin A (oz-apraA), a cyclodepsipeptide isolated from a marine cyanobacterium, promotes the degradation of Hsp90 clients through chaperone-mediated autophagy (CMA). We identify a KFERQ-like motif as a conserved pentapeptide sequence in the kinase domain of epidermal growth factor receptor (EGFR) necessary for recognition as a CMA substrate. Mutation of this motif prevents EGFR degradation by CMA and promotes the degradation of EGFR through the proteasomal pathway in oz-apraA-treated cells. Oz-apraA binds to Hsc70/Hsp70. We propose that apratoxin A inhibits Hsp90 function by stabilizing the interaction of Hsp90 client proteins with Hsc70/Hsp70 and thus prevents their interactions with Hsp90. Our study provides the first examples for the ability of CMA to mediate degradation of membrane receptors and cross talks of CMA and proteasomal degradation mechanisms. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1083/jcb.200810183 |
| 语种 | 英语 |
| WOS记录号 | WOS:000266279900009 |
| 公开日期 | 2013-02-19 |
| 源URL | [http://202.127.28.38/handle/331003/15611]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shen, Shensi,Zhang PT,Lovchik, Martin A.,et al. Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy[J]. J. Cell Biol.,2009,185(4):629-639. |
| APA | Shen, Shensi.,张澎涛.,Lovchik, Martin A..,Li, Ying.,Tang, Liuya.,...&俞强.(2009).Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy.J. Cell Biol.,185(4),629-639. |
| MLA | Shen, Shensi,et al."Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy".J. Cell Biol. 185.4(2009):629-639. |
入库方式： OAI收割
来源：上海有机化学研究所
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