Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21
文献类型：期刊论文
| 作者 | Zhu XM(朱向明) ; Yu B(俞飚) ; Hui YZ(惠永正) ; R. R. Schmidt |
| 刊名 | Eur. J. Org. Chem.
 |
| 出版日期 | 2004 |
| 期号 | 5页码:965-973 |
| ISSN号 | 1434-193X |
| 其他题名 | 免疫佐剂QS-21三糖和四糖部分的合成 |
| 通讯作者 | 朱向明 |
| 英文摘要 | The title trisaccharide and tetrasaccharide moieties have been synthesized as part of our research programme to construct the complex triterpenoid saponin QS-21, a potent immunoadjuvant, which has been used in a series of clinical immunization trials. In view of the unwillingness of glucuronic acid as glycosyl acceptor, the branched glucuronic acid-containing trisaccharide 20 was synthesized from D-glucose, which was in turn glycosylated at positions 2 and 3, followed by oxidation at position 6, in a linear sequence of 15 steps and in good overall yield. The apiose-containing tetrasaccharide 36 was constructed by a linear glycosylation strategy from the non-reducing terminal sugar, D-apiose, which was prepared from D-xylose by a known procedure, also in a linear sequence of 15 steps. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/ejoc.200300580 |
| 语种 | 英语 |
| WOS记录号 | WOS:000220048400003 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/18991]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu XM,Yu B,Hui YZ,et al. Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21[J]. Eur. J. Org. Chem.,2004(5):965-973. |
| APA | 朱向明,俞飚,惠永正,&R. R. Schmidt.(2004).Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21.Eur. J. Org. Chem.(5),965-973. |
| MLA | 朱向明,et al."Synthesis of the trisaccharide and tetrasaccharide moieties of the potent immunoadjuvant QS-21".Eur. J. Org. Chem. .5(2004):965-973. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。