Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells
文献类型：期刊论文
| 作者 | R. C. Y. Ong ; J. Lei ; R. K. Y. Lee ; J. Y. N. Cheung ; K. P. Fung ; C. Lin ; H. P. Ho ; Yu B(俞飚) ; M. Li ; S. K. Kong |
| 刊名 | Cancer Lett.
 |
| 出版日期 | 2008 |
| 卷号 | 261期号:2页码:158-164 |
| ISSN号 | 0304-3835 |
| 其他题名 | Polyphyllin D诱导的线粒体分裂和直接作用于线粒体的诱导耐药HepG2细胞凋亡的行为。 |
| 通讯作者 | S. K. Kong |
| 英文摘要 | We previously showed that polyphyllin D (PD) produced a stronger apoptotic effect in R-HepG2 with multi-drug resistance (MDR) than that in its parent HepG2 cells without MDR. In this study, PD was found to elicit mitochondrial fragmentation in live cells by using total internal reflection fluorescence microscopy (TIRFM). When mitochondria were isolated and treated directly with PD, a stronger swelling, deeper transmembrane depolarization, and more apoptosis-inducing factor (A IF) release were observed from the mitochondria of R-HepG2 than that of HepG2. These observations suggest that PD is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury. (C) 2007 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.canlet.2007.11.005 |
| 语种 | 英语 |
| WOS记录号 | WOS:000254732500004 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/19087]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | R. C. Y. Ong,J. Lei,R. K. Y. Lee,et al. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells[J]. Cancer Lett.,2008,261(2):158-164. |
| APA | R. C. Y. Ong.,J. Lei.,R. K. Y. Lee.,J. Y. N. Cheung.,K. P. Fung.,...&S. K. Kong.(2008).Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.Cancer Lett.,261(2),158-164. |
| MLA | R. C. Y. Ong,et al."Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells".Cancer Lett. 261.2(2008):158-164. |
入库方式： OAI收割
来源：上海有机化学研究所
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