Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling
文献类型：期刊论文
| 作者 | ZHANG LONG ; Jiang HX(姜海霞) ; Cao XX(曹星欣) ; ZHAO HUIYUN ; WANG FAN ; Cui YX(崔育新) ; Jiang B(姜标) |
| 刊名 | Eur. J. Med. Chem.
 |
| 出版日期 | 2009 |
| 卷号 | 44期号:10页码:3961-3972 |
| ISSN号 | 0223-5234 |
| 其他题名 | Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling |
| 通讯作者 | 崔育新 ; 姜标 |
| 英文摘要 | To better use gossypol to find promising anticancer compounds, a series of new and known bis-Schiff base analogs of chiral gossypol were synthesized, and their anticancer activity on HeLa, U87 and M85 cells was tested. The results showed that through a simple chemical modification, less active (+)-gossypol could be converted into more active derivatives. When compared with (-)-gossypol, many more potent compounds that could be the promising anticancer agents were found, and some of them were more potent than the anticancer drug Cisplatin against all three cancer cell lines. By eliminating target functional groups, we observed that the major contributor to the anticancer activity of chiral gossypol seemed to be the phenolic groups, and not the aldehyde groups. Through comprehensive analysis of chiral gossypol analogs, the structure-activity relationships were elaborated. (C) 2009 Elsevier Masson SAS. All rights reserved. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.ejmech.2009.04.025 |
| 语种 | 英语 |
| WOS记录号 | WOS:000269398900018 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/20269]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | ZHANG LONG,Jiang HX,Cao XX,et al. Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling[J]. Eur. J. Med. Chem.,2009,44(10):3961-3972. |
| APA | ZHANG LONG.,姜海霞.,曹星欣.,ZHAO HUIYUN.,WANG FAN.,...&姜标.(2009).Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling.Eur. J. Med. Chem.,44(10),3961-3972. |
| MLA | ZHANG LONG,et al."Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling".Eur. J. Med. Chem. 44.10(2009):3961-3972. |
入库方式： OAI收割
来源：上海有机化学研究所
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