A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer
文献类型：期刊论文
| 作者 | Yan F(阎飞) ; Cao XX(曹星欣) ; Jiang HX(姜海霞) ; Zhao XL(赵小龙) ; Wang JY(王建永) ; Lin YH(林毅晖) ; Liu QL(刘巧玲) ; Zhang C(张琛) ; Jiang B(姜标) ; Guo F(郭方) |
| 刊名 | J. Med. Chem.
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:15页码:5502-5510 |
| ISSN号 | 0022-2623 |
| 其他题名 | A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer |
| 通讯作者 | 姜标 ; 郭方 |
| 英文摘要 | Compound 1 ((-)-gossypol) has been long known as a chemical anticancer agent. With its low water solubility and toxicity, it is not widely used as a commercial drug. To overcome these disadvantages, several novel derivatives of gossypol were designed, synthesized, and analyzed. One of the derivatives, compound 7 (6-aminopenicillanic acid sodium-gossypolone), was identified with great water solubility and anticancer property, suggested by inducing a dramatically decrease in Bcl-2 and Bcl-xL protein expression level found in vitro and growth inhibition of murine colon tumor in vivo. Furthermore, it was also recognized with less toxicity than compound 1 in vivo and significantly increased chemotherapeutic sensitivity against colon cancer in combination with traditional chemotherapeutic agent 5-fluorouracil. Therefore, it is concluded that compound 7 is superior to parent compound 1, and further preclinical studies of compound 7 is necessary for colon cancer therapy. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/jm1001698 |
| 语种 | 英语 |
| WOS记录号 | WOS:000280523300010 |
| 公开日期 | 2013-02-25 |
| 源URL | [http://202.127.28.38/handle/331003/20279]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Yan F,Cao XX,Jiang HX,et al. A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer[J]. J. Med. Chem.,2010,53(15):5502-5510. |
| APA | 阎飞.,曹星欣.,姜海霞.,赵小龙.,王建永.,...&郭方.(2010).A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer.J. Med. Chem.,53(15),5502-5510. |
| MLA | 阎飞,et al."A Novel Water-Soluble Gossypol Derivative Increases Chemotherapeutic Sensitivity and Promotes Growth Inhibition in Colon Cancer".J. Med. Chem. 53.15(2010):5502-5510. |
入库方式： OAI收割
来源：上海有机化学研究所
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