Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b
文献类型：期刊论文
| 作者 | Ye ZQ(叶正清) ; Gao TY(高婷轶) ; Zhao G(赵刚) |
| 刊名 | Tetrahedron
 |
| 出版日期 | 2011 |
| 卷号 | 67期号:33页码:5979-5989 |
| ISSN号 | 0040-4020 |
| 其他题名 | 大环内酯iriomoteolide-1b的对映选择性全合成 |
| 通讯作者 | 赵刚 |
| 英文摘要 | An enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b has been achieved by a convergent protocol, which was featured by an enantioselective organocatalytic transfer hydrogenation of enal, a Julia-Kocienski olefination to establish the C15-C16 E-olefin moiety, a Kulinkovich reaction associated with cyclopropyl-allyl rearrangement to produce allyl stannane and ytterbium triflate and carboxylic acid promoted allylation between allyl stannane and aldehyde with tertiary alcohol at the alpha-position. The construction of macrolide 2 was realized by the successful implementation of RCM utilizing 5 mol % Grubbs's second generation catalyst at room temperature with E-isomer as a single product. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tet.2011.06.025 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293606200017 |
| 公开日期 | 2013-02-26 |
| 源URL | [http://202.127.28.38/handle/331003/20817]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Ye ZQ,Gao TY,Zhao G. Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b[J]. Tetrahedron,2011,67(33):5979-5989. |
| APA | 叶正清,高婷轶,&赵刚.(2011).Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b.Tetrahedron,67(33),5979-5989. |
| MLA | 叶正清,et al."Enantioselective total synthesis of the proposed structure of macrolide iriomoteolide-1b".Tetrahedron 67.33(2011):5979-5989. |
入库方式： OAI收割
来源：上海有机化学研究所
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