Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry
文献类型：期刊论文
| 作者 | Wang ZF ; Cui M ; Song FR ; Lu L ; Liu ZQ ; Liu SY |
| 刊名 | journal of the american society for mass spectrometry
 |
| 出版日期 | 2008 |
| 卷号 | 19期号:7页码:914-922 |
| 关键词 | DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES NEGATIVE-ION MODE NONCOVALENT COMPLEXES TOPOISOMERASE-I PROTOBERBERINE ALKALOIDS G-QUADRUPLEX AMINO SUGAR ESI-MS DRUGS CLEAVAGE |
| ISSN号 | 1044-0305 |
| 通讯作者 | liu zq |
| 中文摘要 | in this study, electrospray ionization mass spectrometry (esi-ms) was used to investigate the binding interactions of ten flavonoid aglycones and ten flavonoid glycosides with dna duplexes. relative binding affinities of the flavonoids toward dna duplexes were estimated based on the fraction of bound dna. the results revealed that the 4'-oh group of flavonoid aglycones was essential for their dna-binding properties. flavonoid glycosides with sugar chain linked on ring a or ring b showed enhanced binding toward the duplexes over their aglycone counterparts, whereas glycosylation of the flavonol quercetin on ring c exhibited a less pronounced effect. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257870100002 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10611]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang ZF,Cui M,Song FR,et al. Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry[J]. journal of the american society for mass spectrometry,2008,19(7):914-922. |
| APA | Wang ZF,Cui M,Song FR,Lu L,Liu ZQ,&Liu SY.(2008).Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry.journal of the american society for mass spectrometry,19(7),914-922. |
| MLA | Wang ZF,et al."Evaluation of flavonoids binding to DNA duplexes by electrospray ionization mass spectrometry".journal of the american society for mass spectrometry 19.7(2008):914-922. |
入库方式： OAI收割
来源：长春应用化学研究所
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