Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry
文献类型：期刊论文
| 作者 | Wang ZF ; Guo XH ; Liu ZQ ; Cui MR ; Song FR ; Liu SY |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2008 |
| 卷号 | 43期号:3页码:327-335 |
| 关键词 | DOUBLE-STRANDED OLIGODEOXYNUCLEOTIDES CYTOTOXIC PROTOBERBERINE ALKALOIDS NONCOVALENT COMPLEXES DUPLEX DNA BERBERINE DIMERS TOPOISOMERASE-I DRUG DISCOVERY ESI-MS AFFINITIES SELECTIVITY |
| ISSN号 | 1076-5174 |
| 通讯作者 | liu zq |
| 中文摘要 | electrospray ionization mass spectrometry (esi-ms) was used to investigate the binding of 13 alkaloids to two gc-rich dna duplexes which are critical sequences in human survivin promoter. negative ion esi-ms was first applied to screen the binding of the alkaloids to the duplexes. six alkaloids (including berberine, jatrorrhizine, palmatine, reserpine, berbamine, and tetrandrine) show complexation with the target dna sequences. relative binding affinities were estimated from the negative ion esi data, and the alkaloids show a binding preference to the duplex with higher gc content. positive ion esi mass spectra of the complexes were also recorded and compared with those obtained in negative ion mode. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254270900005 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10623]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang ZF,Guo XH,Liu ZQ,et al. Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry[J]. journal of mass spectrometry,2008,43(3):327-335. |
| APA | Wang ZF,Guo XH,Liu ZQ,Cui MR,Song FR,&Liu SY.(2008).Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry.journal of mass spectrometry,43(3),327-335. |
| MLA | Wang ZF,et al."Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry".journal of mass spectrometry 43.3(2008):327-335. |
入库方式： OAI收割
来源：长春应用化学研究所
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