Synthesis of 3′,3′-Difluoro-2′- hydroxymethyl-4′,5′-unsaturated Carbocyclic Nucleosides
文献类型：期刊论文
| 作者 | Yang YY(杨严严) ; Xu J(徐军) ; You ZW(游正伟) ; Xu XH(徐修华) ; Qiu XL(邱小龙) ; Qing FL(卿凤翎) |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2007 |
| 卷号 | 9期号:26页码:5437-5440 |
| ISSN号 | 1523-7060 |
| 其他题名 | Synthesis of 3′,3′-Difluoro-2′- hydroxymethyl-4′,5′-unsaturated Carbocyclic Nucleosides |
| 通讯作者 | 卿凤翎 |
| 英文摘要 | 3',3'-DifIuoro-2'-hydroxymethyl-4',5'-unsaturated carbocyclic nucleosides 1-3 have been stereoselectively synthesized from ester 10, which can be conveniently prepared from 2,3-isopropylidene-D-glyceraidehyde 7 in five steps. The whole synthesis highlighted the stereoselective Reformatskii-Claisen rearrangement, ring-closing metathesis (RCM), and palladium-catalyzed allylic alkylation, in which the regioselectivity was reversed from that of nonfluorinated substrates. |
| 学科主题 | 氟化学 ; 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol7023955 |
| 语种 | 英语 |
| 公开日期 | 2013-02-22 |
| 源URL | [http://202.127.28.38/handle/331003/17613]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Yang YY,Xu J,You ZW,et al. Synthesis of 3′,3′-Difluoro-2′- hydroxymethyl-4′,5′-unsaturated Carbocyclic Nucleosides[J]. Org. Lett.,2007,9(26):5437-5440. |
| APA | 杨严严,徐军,游正伟,徐修华,邱小龙,&卿凤翎.(2007).Synthesis of 3′,3′-Difluoro-2′- hydroxymethyl-4′,5′-unsaturated Carbocyclic Nucleosides.Org. Lett.,9(26),5437-5440. |
| MLA | 杨严严,et al."Synthesis of 3′,3′-Difluoro-2′- hydroxymethyl-4′,5′-unsaturated Carbocyclic Nucleosides".Org. Lett. 9.26(2007):5437-5440. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。