Selective synthesis of poly-substituted fluorine-containing pyridines and dihydropyrimidines via cascade C-F bond cleavage protocol
文献类型：期刊论文
| 作者 | Chen ZX(陈资衔) ; Zhu JT(祝江涛) ; Xie HB(谢海波) ; Li S(李删) ; Wu YM(吴永明) ; Gong YF(龚跃发) |
| 刊名 | Org. Biomol. Chem.
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:16页码:5682-5691 |
| ISSN号 | 1477-0520 |
| 其他题名 | 通过串联的C-F键断裂策略, 选择性合成含氟多取代吡啶和二氢嘧啶类化合物 |
| 通讯作者 | 吴永明 ; 龚跃发 |
| 英文摘要 | Fluorinated azaheterocycles are frequently found in pharmaceuticals, drug candidates, ligands for transition metal catalysts, and other molecular functional materials, so efficient methods for the synthesis of these compounds are of significant value. We herein describe a selective strategy for the synthesis of poly-substituted pyridines and fluoroalkyl dihydropyrimidines based on C-F bond breaking of the anionically activated fluoroalkyl group. An array of pyridines and dihydropyrimidines were prepared through this domino process in high yields under noble metal catalyst-free conditions, making this method a valuable supplement to azaheterocycle synthesis. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1039/c1ob05371j |
| 语种 | 英语 |
| WOS记录号 | WOS:000293230300013 |
| 公开日期 | 2013-04-10 |
| 源URL | [http://202.127.28.38/handle/331003/25169]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen ZX,Zhu JT,Xie HB,et al. Selective synthesis of poly-substituted fluorine-containing pyridines and dihydropyrimidines via cascade C-F bond cleavage protocol[J]. Org. Biomol. Chem.,2011,9(16):5682-5691. |
| APA | 陈资衔,祝江涛,谢海波,李删,吴永明,&龚跃发.(2011).Selective synthesis of poly-substituted fluorine-containing pyridines and dihydropyrimidines via cascade C-F bond cleavage protocol.Org. Biomol. Chem.,9(16),5682-5691. |
| MLA | 陈资衔,et al."Selective synthesis of poly-substituted fluorine-containing pyridines and dihydropyrimidines via cascade C-F bond cleavage protocol".Org. Biomol. Chem. 9.16(2011):5682-5691. |
入库方式： OAI收割
来源：上海有机化学研究所
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