Hydration of drug-DNA complexes: Greater water uptake for adriamycin compared to daunomycin
文献类型：期刊论文
| 作者 | Yu HJ ; Ren JS ; Chaires JB ; Qu XG |
| 刊名 | journal of medicinal chemistry
 |
| 出版日期 | 2008 |
| 卷号 | 51期号:19页码:5909-5911 |
| 关键词 | INTERCALATION REACTIONS BINDING DYNAMICS DESIGN ANALOG |
| ISSN号 | 0022-2623 |
| 通讯作者 | qu xg |
| 中文摘要 | water is an integral part of dna, and the conserved water molecules at the binding sites can modulate drug binding to dna or protein. we report here that anthracycline antitumor antibiotics, adriamycin (am) and daunomycin (dm), binding to dna is accompanied by different hydration changes, with am binding resulting in the uptake of about twice as many water molecules as dm. these results indicate that water is playing an important role in drug binding to dna. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259760500006 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10835]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu HJ,Ren JS,Chaires JB,et al. Hydration of drug-DNA complexes: Greater water uptake for adriamycin compared to daunomycin[J]. journal of medicinal chemistry,2008,51(19):5909-5911. |
| APA | Yu HJ,Ren JS,Chaires JB,&Qu XG.(2008).Hydration of drug-DNA complexes: Greater water uptake for adriamycin compared to daunomycin.journal of medicinal chemistry,51(19),5909-5911. |
| MLA | Yu HJ,et al."Hydration of drug-DNA complexes: Greater water uptake for adriamycin compared to daunomycin".journal of medicinal chemistry 51.19(2008):5909-5911. |
入库方式： OAI收割
来源：长春应用化学研究所
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