Rapid label-free detection of metal-induced Alzheimer's amyloid beta peptide aggregation by electrochemical method
文献类型：期刊论文
| 作者 | Geng J ; Yu HJ ; Ren JS ; Qu XG |
| 刊名 | electrochemistry communications
 |
| 出版日期 | 2008 |
| 卷号 | 10期号:11页码:1797-1800 |
| 关键词 | A-BETA FIBRIL FORMATION GOLD ELECTRODES ALPHA-SYNUCLEIN CYTOCHROME-C IN-VITRO DISEASE PROTEIN COPPER BINDING |
| ISSN号 | 1388-2481 |
| 通讯作者 | qu xg |
| 中文摘要 | amyloid beta peptide plays a critical role in the pathogenesis of alzheimer's disease (ad). metal ions are highly enriched in cerebral amyloid deposits in ad and are proposed to be able to mediate a beta conformation. therefore, a rapid, low-cost, and sensitive detection of metal-induced a beta aggregation and their relation to ad is clearly needed for the clinical diagnosis and treatment. in this report, we study metal-induced a beta aggregation by a rapid, label-free electrochemical method and monitor both the aggregation kinetics and the morphology in the absence or presence of zn (ii) and cu (ii). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260992900036 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10837]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Geng J,Yu HJ,Ren JS,et al. Rapid label-free detection of metal-induced Alzheimer's amyloid beta peptide aggregation by electrochemical method[J]. electrochemistry communications,2008,10(11):1797-1800. |
| APA | Geng J,Yu HJ,Ren JS,&Qu XG.(2008).Rapid label-free detection of metal-induced Alzheimer's amyloid beta peptide aggregation by electrochemical method.electrochemistry communications,10(11),1797-1800. |
| MLA | Geng J,et al."Rapid label-free detection of metal-induced Alzheimer's amyloid beta peptide aggregation by electrochemical method".electrochemistry communications 10.11(2008):1797-1800. |
入库方式： OAI收割
来源：长春应用化学研究所
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