Targeted RNA interference of cyclin A(2) mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells
文献类型：期刊论文
| 作者 | Wang XH ; Ren JS ; Qu XG |
| 刊名 | chemmedchem
 |
| 出版日期 | 2008 |
| 卷号 | 3期号:6页码:940-945 |
| ISSN号 | 1860-7179 |
| 关键词 | A EXPRESSION MAMMALIAN-CELLS DNA-REPLICATION CDK INHIBITORS IN-VIVO DELIVERY TRANSPORTERS CANCER GENE BIODISTRIBUTION |
| 通讯作者 | wang xh |
| 中文摘要 | cyclin a(2) plays critical role in dna replication, transcription, and cell cycle regulation. its overexpression has been detected and related to many types of cancers including leukemia, suggesting that suppression of cyclin a(2) would be an attractive strategy to prevent tumor progression. herein, we apply functionalized single wall carbon nanotubes (f-swnts) to carry small interfering rna (sirna) into k562 cells and determine whether inhibition of cyclin a(2) would be a potential therapeutic target for chronic myelogenous leukemia. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256975900009 |
| 公开日期 | 2010-04-14 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/10843]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang XH,Ren JS,Qu XG. Targeted RNA interference of cyclin A(2) mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells[J]. chemmedchem,2008,3(6):940-945. |
| APA | Wang XH,Ren JS,&Qu XG.(2008).Targeted RNA interference of cyclin A(2) mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells.chemmedchem,3(6),940-945. |
| MLA | Wang XH,et al."Targeted RNA interference of cyclin A(2) mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells".chemmedchem 3.6(2008):940-945. |
入库方式： OAI收割
来源：长春应用化学研究所
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