Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01
文献类型：期刊论文
| 作者 | Luo, XW; Zhou, XF; Lin, XP; Qin, XC; Zhang, TY; Wang, JF; Tu, ZC; Yang, B; Liao, SR; Tian, YQ |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2017 |
| 卷号 | 31期号:16页码:1958-1962 |
| 关键词 | Deep sea fungi Aspergillus sp anti-tuberculosis alkaloids |
| 通讯作者 | taohm@smu.edu.cn |
| 中文摘要 | Eleven diketopiperazine and fumiquinazoline alkaloids (1-11) together with a tetracyclic triterpenoid helvolic acid (12) were obtained from the cultures of a deep-sea derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of these compounds (1-12) were determined mainly by the extensive NMR, ESIMS spectra data and by comparison with previously described compounds. Besides, anti-tuberculosis, cytotoxic, antibacterial, COX-2 inhibitory and antiviral activities of these compounds were evaluated. Gliotoxin (3), 12,13-dihydroxy-fumitremorgin C (11) and helvolic acid (12) exhibited very strong anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50 values of <0.03, 2.41 and 0.894M, respectively, which was here reported for the first time. Meanwhile gliotoxin also displayed significant selective cytotoxicities against K562, A549 and Huh-7 cell lines with the IC50 values of 0.191, 0.015 and 95.4M, respectively. [GRAPHICS] . |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16223]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Luo, XW,Zhou, XF,Lin, XP,et al. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01[J]. NATURAL PRODUCT RESEARCH,2017,31(16):1958-1962. |
| APA | Luo, XW.,Zhou, XF.,Lin, XP.,Qin, XC.,Zhang, TY.,...&Liu, YH.(2017).Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01.NATURAL PRODUCT RESEARCH,31(16),1958-1962. |
| MLA | Luo, XW,et al."Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp SCSIO Ind09F01".NATURAL PRODUCT RESEARCH 31.16(2017):1958-1962. |
入库方式： OAI收割
来源：南海海洋研究所
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