Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502
文献类型：期刊论文
| 作者 | Huang, ZH; Nong, XH; Ren, Z; Wang, J; Zhang, XY; Qi, SH |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:4页码:787-791 |
| 关键词 | Aspergillus versicolor Phenolic compounds Antioxidant Antiviral Antifouling |
| 通讯作者 | shuhuaqi@scsio.ac.cn |
| 中文摘要 | Chemical investigation of the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502 resulted in the isolation of three new anthraquinones, aspergilols G-I (1-3), one new diphenyl ether, 4-carbglyceryl-3,3'dihydroxy-5,5'-dimethyldiphenyl ether (4), and one new benzaldehyde derivative, 2,4-dihydroxy-6-(4methoxy-2-oxopentyl)-3-methylbenzaldehyde (5), along with 23 known phenolic compounds (6-28). The structures of new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 3 was established by CD spectrum and the modified Mosher method. Compounds 2, 3 and 9 had evident antiviral activity towards HSV-1 with EC50 values of 4.68, 6.25, and 3.12 mu M, respectively. Compounds 15, 18, 20 and 22-24 showed more potent antioxidant activity than L-ascorbic acid with IC50 values of 18.92-52.27 mu M towards DPPH radicals. Comparison of the structures and antioxidant activities of 1-28 suggests that the number of phenolic hydroxyl group that can freely rotate can significantly affect the antioxidant activity of phenolic compounds. In addition, 4, 22-24 and 27 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 1.28, 2.61, 5.48, 1.59, and 3.40 mu g/ml, respectively. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16240]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang, ZH,Nong, XH,Ren, Z,et al. Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(4):787-791. |
| APA | Huang, ZH,Nong, XH,Ren, Z,Wang, J,Zhang, XY,&Qi, SH.(2017).Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(4),787-791. |
| MLA | Huang, ZH,et al."Anti-HSV-1, antioxidant and antifouling phenolic compounds from the deep-sea-derived fungus Aspergillus versicolor SCSIO 41502".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.4(2017):787-791. |
入库方式： OAI收割
来源：南海海洋研究所
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