Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation
文献类型：期刊论文
| 作者 | Chen, ST; Wang, JF; Wang, Z; Lin, XP; Zhao, BX; Kaliaperumal, K; Liao, XJ; Tu, ZC; Li, JL; Xu, SH |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017 |
| 卷号 | 117页码:71-78 |
| 关键词 | Isocoumarin Merosesquiterpenoid Citrinin dimer Alkaloid Cytotoxic COX-2 |
| 通讯作者 | txush@jnu.edu.cn ; yonghongliu@scsio.ac.cn |
| 中文摘要 | Five new compounds, including a cytotoxic dimeric isocoumarin, bipenicilisorin (1), a merosesquiterpenoid, yaminterritrem C (2), a citrinin dimer, penicitrinone F (3), a alkaloid, terremide D (4), and a delta-Valerolacton, (E)-4-(propen-1-yl)-5,6-dihydro-2H-pyran-2-one (5), along with ten known compounds (6-15) were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 1 exhibited significant cytotoxic activities against K562, A549, and Huh-7 cell lines with IC50 values of 6.78, 6.94, and 2.59 mu M, respectively. Compound 3 exhibited moderate inhibitory activity against EV71 with IC50 value of 14.50 mu M. In addition, 13 and 14 showed specific COX-2 inhibitory activities with IC50 values of 1.09 and 1.97 mu M, respectively. (C) 2017 Published by Elsevier B.V. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16245]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, ST,Wang, JF,Wang, Z,et al. Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation[J]. FITOTERAPIA,2017,117:71-78. |
| APA | Chen, ST.,Wang, JF.,Wang, Z.,Lin, XP.,Zhao, BX.,...&Liu, YH.(2017).Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation.FITOTERAPIA,117,71-78. |
| MLA | Chen, ST,et al."Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation".FITOTERAPIA 117(2017):71-78. |
入库方式： OAI收割
来源：南海海洋研究所
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