BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides
文献类型：期刊论文
| 作者 | Cai, J; Wei, SN; Yu, DP; Song, R; Lu, YS; Wu, ZH; Qin, QW; Jian, JC |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 64页码:407-413 |
| 关键词 | Epinephelus coioides BNIP3 Singapore grouper iridovirus (SGIV) Viral infection |
| 通讯作者 | qinqiwei64@outlook.com ; jianjc@gdou.edu.cn |
| 中文摘要 | BNIP3 is a kind of BH3-only protein that induces both cell death and autophagy. Here, a BNIP3 gene (EcBNIP3) was identified from orange spotted grouper, Epinephelus coioides. EcBNIP3 possessed 236 amino acids residues, contained a conservative BNIP3 domain and a transmembrane region. Besides, EcBNIP3 expressed at a relative high level in heart and spleen. EcBNIP3 transcript was up-regulated after SGIV infection in vitro. Subcellular localization analysis revealed that EcBNIP3 was predominantly localized in the cytoplasm and co-localized with mitochondria. In addition, overexpression EcBNIP3 accelerated SGIV infection induced cell death but inhibited viral genes transcription. Taken together, these results provided new evidence that fish BNIP3 might involved in response to virus infection. (C) 2017 Published by Elsevier Ltd. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16275]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Cai, J,Wei, SN,Yu, DP,et al. BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides[J]. FISH & SHELLFISH IMMUNOLOGY,2017,64:407-413. |
| APA | Cai, J.,Wei, SN.,Yu, DP.,Song, R.,Lu, YS.,...&Jian, JC.(2017).BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides.FISH & SHELLFISH IMMUNOLOGY,64,407-413. |
| MLA | Cai, J,et al."BNIP3, a cell pro-apoptotic protein, involved in response to viral infection in orange spotted grouper, Epinephelus coioides".FISH & SHELLFISH IMMUNOLOGY 64(2017):407-413. |
入库方式： OAI收割
来源：南海海洋研究所
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