Effects of chronic ammonia exposure on ammonia metabolism and excretion in marine medaka Oryzias melastigma
文献类型：期刊论文
| 作者 | Gao, N; Zhu, LM; Guo, ZQ; Yi, MS; Zhang, L |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 65页码:226-234 |
| 关键词 | Oryzias melastigma Chronic exposure Toxicity Ammonia excretion Amino acid catabolism |
| 通讯作者 | yimsh@mail.sysu.edu.cn ; zhangli@scsio.ac.cn |
| 中文摘要 | Ammonia is highly toxic to aquatic organisms, but whether ammonia excretion or ammonia metabolism to less toxic compounds is the major strategy for detoxification in marine fish against chronic ammonia exposure is unclear to date. In this study, we investigated the metabolism and excretion of ammonia in marine medaka Oryzias melastigma during chronic ammonia exposure. The fish were exposed to 0, 0.1, 0.3, 0.6, and 1.1 mmol l(-1) NH4Cl spiked seawater for 8 weeks. Exposure of 0.3-1.1 mmol l(-1) NH4Cl had deleterious effects on the fish, including significant reductions in growth, feed intake, and total protein content. However, the fish could take strategies to detoxify ammonia. The tissue ammonia (T-Amm) in the 0.3-1.1 mmol l(-1) NH4Cl treatments was significantly higher than those in the 0 and 0.1 mmol l(-1) NH4Cl treatments after 2 weeks of exposure, but it recovered with prolonged exposure time, ultimately reaching the control level after 8 weeks. The amino acid catabolic rate decreased to reduce the gross ammonia production with the increasing ambient ammonia concentration. The concentrations of most metabolites remained constant in the 0-0.6 mmol l(-1) NH4Cl treatments, whereas 5 amino acids and 3 energy metabolism-related metabolites decreased in the 1.1 mmol l(-1) NH4Cl treatment. J(Amm) steadily increased in ambient ammonia from 0 to 0.6 mmol l(-1) and slightly decreased when the ambient ammonia concentration increased to 1.1 mmol l(-1). Overall, marine medaka cope with sublethal ammonia environment by regulating the tissue T-Amm via reducing the ammonia production and increasing ammonia excretion. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16291]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Gao, N,Zhu, LM,Guo, ZQ,et al. Effects of chronic ammonia exposure on ammonia metabolism and excretion in marine medaka Oryzias melastigma[J]. FISH & SHELLFISH IMMUNOLOGY,2017,65:226-234. |
| APA | Gao, N,Zhu, LM,Guo, ZQ,Yi, MS,&Zhang, L.(2017).Effects of chronic ammonia exposure on ammonia metabolism and excretion in marine medaka Oryzias melastigma.FISH & SHELLFISH IMMUNOLOGY,65,226-234. |
| MLA | Gao, N,et al."Effects of chronic ammonia exposure on ammonia metabolism and excretion in marine medaka Oryzias melastigma".FISH & SHELLFISH IMMUNOLOGY 65(2017):226-234. |
入库方式： OAI收割
来源：南海海洋研究所
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