Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito
文献类型：期刊论文
| 作者 | Wang, JL; Saha, TT; Zhang, Y; Zhang, CY; Raikhel, AS |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
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| 出版日期 | 2017 |
| 卷号 | 292期号:24页码:10306-10315 |
| 通讯作者 | alexander.raikhel@ucr.edu |
| 中文摘要 | Juvenile hormone (JH) controls many biological activities in insects, including development, metamorphosis, and reproduction. In the Aedes aegypti mosquito, a vector of dengue, yellow fever, chikungunya, and zika viruses, the metabolic tissue (the fat body, which is an analogue of the vertebrate liver) produces yolk proteins for developing oocytes. JH is important for the fat body to acquire competence for yolk protein production. However, the molecular mechanisms of how JH promotes mosquito reproduction are not completely understood. In this study we show that stimulation of the JH receptor methoprene-tolerant (Met) activates expression of genes encoding the regulator of ribosome synthesis 1 (RRS1) and six ribosomal proteins (two ribosomal large subunit proteins, two ribosomal small subunit proteins, and two mitochondrial ribosomal proteins). Moreover, RNAi-mediated depletion of RRS1 decreased biosynthesis of the ribosomal protein L32 (RpL32). Depletion of Met, RRS1, or RpL32 led to retardation of ovarian growth and reduced mosquito fecundity, which may at least in part have resulted from decreased vitellogenin protein production in the fat body. In summary, our results indicate that JH is critical for inducing the expression of ribosomal protein genes and demonstrate that RRS1 mediates the JH signal to enhance both ribosomal biogenesis and vitellogenesis. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16293]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, JL,Saha, TT,Zhang, Y,et al. Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2017,292(24):10306-10315. |
| APA | Wang, JL,Saha, TT,Zhang, Y,Zhang, CY,&Raikhel, AS.(2017).Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito.JOURNAL OF BIOLOGICAL CHEMISTRY,292(24),10306-10315. |
| MLA | Wang, JL,et al."Juvenile hormone and its receptor methoprene-tolerant promote ribosomal biogenesis and vitellogenesis in the Aedes aegypti mosquito".JOURNAL OF BIOLOGICAL CHEMISTRY 292.24(2017):10306-10315. |
入库方式： OAI收割
来源：南海海洋研究所
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