Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089
文献类型：期刊论文
| 作者 | Jiang, XD; Zhang, QB; Zhu, YG; Nie, FL; Wu, ZC; Yang, CF; Zhang, LP; Tian, XP; Zhang, CS |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2017 |
| 卷号 | 73期号:26页码:3585-3590 |
| 关键词 | Marine actinomycetes Benzofluorene Biosynthesis Natural products Nenestatin A |
| 通讯作者 | czhang2006@gmail.com |
| 中文摘要 | Benzofluorene-containing angucyclines, such as lomaiviticins, kinamycins, and fluostatins, have attracted increasing attentions on chemical synthesis and biosynthesis due to their unique structures and potent biological activities. Our continuous searching for novel natural products from deep-sea derived actinomycetes led to the discovery of nenestatin A (1), a benzo[b]fluorene compound possessing a carbon scaffold similar to the monomeric lomaiviticins, from the deep sea-derived Micromonospora echinospora SCSIO 04089. In addition, the biosynthetic gene cluster of nenestatin A (nes) was identified by a genome sequencing approach and comparative bioinformatics analysis with the lomaiviticin biosynthetic gene clusters. The nes-gene cluster was further verified by in vivo gene disruption experiments to afford a biosynthetic intermediate homo-dehydrorabelomycin E (2). This study adds a new member to the growing family of benzofluorene angucyclines and paves the way for further biosynthetic investigations. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16300]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Jiang, XD,Zhang, QB,Zhu, YG,et al. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089[J]. TETRAHEDRON,2017,73(26):3585-3590. |
| APA | Jiang, XD.,Zhang, QB.,Zhu, YG.,Nie, FL.,Wu, ZC.,...&Zhang, CS.(2017).Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089.TETRAHEDRON,73(26),3585-3590. |
| MLA | Jiang, XD,et al."Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089".TETRAHEDRON 73.26(2017):3585-3590. |
入库方式： OAI收割
来源：南海海洋研究所
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