Real-Time Study of Genomic DNA Structural Changes upon Interaction with Small Molecules Using Dual-Polarization Interferometry
文献类型：期刊论文
| 作者 | Wang J ; Xu XW ; Zhang ZX ; Yang F ; Yang XR |
| 刊名 | analytical chemistry
 |
| 出版日期 | 2009 |
| 卷号 | 81期号:12页码:4914-4921 |
| 关键词 | DIBLOCK PHOSPHORYLCHOLINE COPOLYMERS SURFACE-PLASMON RESONANCE STRANDED DNA CONFORMATIONAL-CHANGES ETHIDIUM-BROMIDE DRUG-BINDING QCM-D IMMOBILIZATION SINGLE INTERCALATION |
| ISSN号 | 0003-2700 |
| 通讯作者 | yang xr |
| 中文摘要 | the structural changes of genomic dna upon interaction with small molecules have been studied in real time using dual-polarization interferometry (dpi). native or thermally denatured dna was immobilized on the silicon oxynitride surface via a preadsorbed poly(ethylenimine) (pei) layer. the mass loading was similar for both types of dna, however, native dna formed a looser and thicker layer due to its rigidity, unlike the more flexible denatured dna, which mixed with pei to form a denser and thinner layer. ethidium bromide (etbr), a classical intercalator, induced the large thickness decrease and density increase of native dna (double-stranded), but a slight increase in both the thickness and density of denatured dna (partial single-stranded). |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266969700031 |
| 公开日期 | 2010-05-04 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/11189]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang J,Xu XW,Zhang ZX,et al. Real-Time Study of Genomic DNA Structural Changes upon Interaction with Small Molecules Using Dual-Polarization Interferometry[J]. analytical chemistry,2009,81(12):4914-4921. |
| APA | Wang J,Xu XW,Zhang ZX,Yang F,&Yang XR.(2009).Real-Time Study of Genomic DNA Structural Changes upon Interaction with Small Molecules Using Dual-Polarization Interferometry.analytical chemistry,81(12),4914-4921. |
| MLA | Wang J,et al."Real-Time Study of Genomic DNA Structural Changes upon Interaction with Small Molecules Using Dual-Polarization Interferometry".analytical chemistry 81.12(2009):4914-4921. |
入库方式： OAI收割
来源：长春应用化学研究所
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