Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives
文献类型：期刊论文
| 作者 | Wei, Lijie1,2; Li, Qing1 ; Tan, Wenqiang1,2; Dong, Fang1; Luan, Fang1,2; Guo, Zhanyong1,2; Li, Q
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| 刊名 | MOLECULES
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| 出版日期 | 2017-03-01 |
| 卷号 | 22期号:3页码:501 |
| 关键词 | single quaternized chitosan double quaternized chitosan chemical modification antioxidant activity |
| ISSN号 | 1420-3049 |
| 产权排序 | [Wei, Lijie; Li, Qing; Tan, Wenqiang; Dong, Fang; Luan, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Tan, Wenqiang; Luan, Fang; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Li, Q ; Guo, ZY (reprint author),Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. ; Guo, ZY (reprint author),Show the Organization-Enhanced name(s) Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Email:qli@yic.ac.cn ; zhanyongguo@hotmail.com |
| 英文摘要 | With the specialty of improving the water solubility of chitosan, quaternary ammonium salts have broadened the application of this polysaccharide in food, medicine and pesticides. To identify the effect of quaternary ammonium salts' quantity, single quaternized chitosan N-phenmethyl-N,N-dimethyl chitosan (PDCS), double quaternized chitosan N-(1-pyridylmethyl-2-ylmethyl)-N,N-dimethyl chitosan (MP2MDCS), N-(1-pyridylmethyl-3-ylmethyl)-N,N-dimethyl chitosan (MP3MDCS), and N-(1-pyridylmethyl-4-ylmethyl)-N,N-dimethyl chitosan (MP4MDCS) were designed and synthesized successfully through chemical modification of chitosan. Besides, three kinds of antioxidant activities, including hydroxyl radicals, superoxide radicals, and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radicals were tested in vitro. As shown in this paper, the scavenging ability was ranking in order of MP3MDC > MP4MDCS > MP2MDCS > PDCS > chitosan at 1.6 mg/mL in all assays. All double quaternary ammonium salts were better than chitosan or the single quaternary ammonium salt. In addition, MP3MDCS could scavenge hydroxyl radicals totally at 1.6 mg/mL. MP2MDCS and MP4MDCS with more than 90% scavenging indices both had great scavenging ability on hydroxyl radicals or DPPH radicals. Furthermore, these data demonstrated that the increasing number of the positive charge would improve the antioxidant property of chitosan derivatives, and the N-pyridinium position would influence the scavenging radical ability. |
| 学科主题 | Chemistry |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | RADICALS SCAVENGING ACTIVITY ; CARBOXYMETHYL CHITOSAN ; ANTIBACTERIAL ACTION ; DISEASE ; DESIGN ; CHITIN ; AGENT |
| 收录类别 | SCI |
| 原文出处 | 10.3390/molecules22030501 |
| 语种 | 英语 |
| WOS记录号 | WOS:000398743500159 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/22015]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 烟台海岸带研究所_污染过程与控制实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Lijie,Li, Qing,Tan, Wenqiang,et al. Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives[J]. MOLECULES,2017,22(3):501. |
| APA | Wei, Lijie.,Li, Qing.,Tan, Wenqiang.,Dong, Fang.,Luan, Fang.,...&Li, Q.(2017).Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives.MOLECULES,22(3),501. |
| MLA | Wei, Lijie,et al."Synthesis, Characterization, and the Antioxidant Activity of Double Quaternized Chitosan Derivatives".MOLECULES 22.3(2017):501. |
入库方式： OAI收割
来源：烟台海岸带研究所
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