Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway
文献类型：期刊论文
| 作者 | Li, Chengcheng1; Yu, Yan1; Li, Wenjun2 ; Liu, Bo1; Jiao, Xudong2; Song, Xinyu1; Lv, Changjun3; Qin, Song2
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-07-19 |
| 卷号 | 7 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and a-smooth muscle actin (a-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28. Moreover, PC greatly decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and myeloperoxidase (MPO) at the earlier time. Reduced expression of key genes in the TLR2 pathway was also detected. Compared with WT mice, TLR2-deficient mice exhibited less injury, and the protective effect of PC was partly diminished in this background. These data indicate the anti-fibrotic effects of PC may be mediated by reducing W/D ratio, MPO, IL-6, TNF-alpha, protecting type I alveolar epithelial cells, inhibiting fibroblast proliferation, attenuating epithelial-mesenchymal transitions (EMT) and reducing oxidative stress. The TLR2-MyD88-NF-kappa B pathway plays an important role in PC-mediated reduction in pulmonary fibrosis. |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ACUTE LUNG INJURY ; C-PHYCOCYANIN ; EPITHELIAL-CELLS ; MESENCHYMAL TRANSITION ; GENE-EXPRESSION ; KAPPA-B ; MICE ; INFLAMMATION ; RATS ; SPIRULINA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000405894200061 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/22520]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 3.Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Chengcheng,Yu, Yan,Li, Wenjun,et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Li, Chengcheng.,Yu, Yan.,Li, Wenjun.,Liu, Bo.,Jiao, Xudong.,...&Qin, Song.(2017).Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway.SCIENTIFIC REPORTS,7. |
| MLA | Li, Chengcheng,et al."Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-kappa B signaling pathway".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：烟台海岸带研究所
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