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Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum

文献类型：期刊论文

作者Cong, Ming; Wu, Huifeng1,2; Yang, Haiping3; Zhao, Jianmin1,2; Lv, Jiasen4; Wu, HF
刊名ECOTOXICOLOGY
出版日期2017-04-01
卷号26期号:3页码:459-469
关键词Ammonia nitrogen Gill damage Neurotoxicity Ruditapes philippinarum
ISSN号0963-9292
产权排序[Wu, Huifeng; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Wu, Huifeng; Zhao, Jianmin] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China; [Yang, Haiping] Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China; [Lv, Jiasen] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
通讯作者Wu, HF
英文摘要Ammonia nitrogen has been a potential menace to aquatic animals along the coastline of China. Presently, the toxicological effects of ammonia nitrogen were mainly concentrated on fishes, while little attention has been paid to molluscs. In this study, the clam Ruditapes philippinarum was used as the target animal to investigate the toxic effects of ammonia nitrogen. Our results showed that ammonia exposure could significantly reduce the integrity of lysosomes in a dose-dependent manner. Metabolite analysis revealed that exposure doses and duration time of ammonia nitrogen could affect the variation profiles of gill metabolites. In detail, branched chain amino acids, glutamate, choline and phosphocholine were significantly decreased after a one-day exposure. Inosine and phenylalanine were found significantly increased and ATP was decreased after a three-day exposure. The changes of metabolites implied that metabolisms of muscle element, neurotransmission and cell apoptosis of gill tissues would be affected by ammonia exposure. Such inferences were supported by the diminished muscle element, decreased concentrations of catecholamines and increased apoptosis rates, respectively. Therefore, we take advantage of metabolomics integrated with conventional biological assays to find out that ammonia exposure could cause lysosome instability, metabolic disturbance, aberrant gill structures and changes to neurotransmitters, and would result in mollusk gill dysfunction in feeding, respiration and immunity.
学科主题Environmental Sciences & Ecology ; Toxicology
研究领域[WOS]Environmental Sciences & Ecology ; Toxicology
关键词[WOS]LYSOSOMAL MEMBRANE STABILITY ; APOPTOSIS ; TOXICITY ; STRESS ; NMR ; IDENTIFICATION ; SPECTROSCOPY ; METABOLOMICS ; BIOMARKERS ; CHALLENGE
收录类别SCI
原文出处10.1007/s10646-017-1777-4
语种英语
WOS记录号WOS:000399817400016
源URL[http://ir.yic.ac.cn/handle/133337/22056]  
专题烟台海岸带研究所_污染过程与控制实验室
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Wu, HF
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
3.Inst Oceanol & Marine Fisheries, Nantong 226007, Peoples R China
4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714		 Cong, Ming,Wu, Huifeng,Yang, Haiping,et al. Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum[J]. ECOTOXICOLOGY,2017,26(3):459-469.
APA Cong, Ming,Wu, Huifeng,Yang, Haiping,Zhao, Jianmin,Lv, Jiasen,&Wu, HF.(2017).Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum.ECOTOXICOLOGY,26(3),459-469.
MLA Cong, Ming,et al."Gill damage and neurotoxicity of ammonia nitrogen on the clam Ruditapes philippinarum".ECOTOXICOLOGY 26.3(2017):459-469.

入库方式： OAI收割

来源：烟台海岸带研究所

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