Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus
文献类型：期刊论文
| 作者 | Sun, Lina1; Sun, Jingchun1 ; Xu, Qinzeng3; Li, Xiaoni1,2; Zhang, Libin1; Yang, Hongsheng1
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| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 22页码:32-38 |
| 关键词 | Sea cucumber Metabolic responses Gene expression Intestine regeneration |
| 英文摘要 | Sea cucumbers are excellent models for studying organ regeneration due to their striking capacity to regenerate most of their viscera after evisceration. In this study, we applied NMR-based metabolomics to determine the metabolite changes that occur during the process of intestine regeneration in sea cucumbers. Partial least-squares discriminant analysis showed that there was significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration (dpe) and normal intestines. Changes in the concentration of 13 metabolites related to regeneration were observed and analyzed. These metabolites included leucine, isoleucine, valine, arginine, glutamate, hypotaurine, dimethylamine, N,N-dimethylglycine, betaine, taurine, inosine, homarine, and histidine. Three important genes (betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase) were differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration. These results provide an important basis for studying regenerative mechanisms and developing regenerative matrixes. (C) 2017 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402220500004 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/136847]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.State Ocean Adm, Inst Oceanog 1, Key Lab Marine Ecol & Environm Sci & Engn, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Lina,Sun, Jingchun,Xu, Qinzeng,et al. Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2017,22:32-38. |
| APA | Sun, Lina,Sun, Jingchun,Xu, Qinzeng,Li, Xiaoni,Zhang, Libin,&Yang, Hongsheng.(2017).Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,22,32-38. |
| MLA | Sun, Lina,et al."Metabolic responses to intestine regeneration in sea cucumbers Apostichopus japonicus".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 22(2017):32-38. |
入库方式： OAI收割
来源：海洋研究所
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