Local-to-remote cortical connectivity in amnestic mild cognitive impairment
文献类型:期刊论文
作者 | Zhang, Yi-Wen1,2; Zhao, Zhi-Lian3,4; Qi, Zhigang3,4; Hu, Yang1,2; Wang, Yin-Shan1,2; Sheng, Can5; Sun, Yu5; Wang, Xiaoni5; Jiang, Li-Li1,2,6; Yan, Chao-Gan1,2,7 |
刊名 | NEUROBIOLOGY OF AGING |
出版日期 | 2017-08-01 |
卷号 | 56期号:0页码:138-149 |
ISSN号 | 0197-4580 |
关键词 | Amnestic mild cognitive impairment Functional homogeneity Local connectivity Remote connectivity Default mode network |
英文摘要 | Alterations in both local and remote connectivity were reported in amnestic mild cognitive impairment aMCI) patients but rarely in the same group of patients. In the present study, we employed a novel resting-state functional magnetic resonance imaging (rfMRI) connectome index, regional functional homogeneity on the 2-dimensional cortical surface, to detect full-cortex vertex-wise changes of the local rfMRI connectivity in 32 aMCI patients compared with 40 healthy controls. We further used the seedbased functional connectivity to explore the remote rfMRI connectivity in aMCI. The results revealed significantly lower local connectivity in the default network and higher local connectivity in the somatomotor network in aMCI patients. Abnormal remote connectivity relevant to local connectivity was primarily detectable within the default network (decrease) and in the somatomotor and attention networks (increase). The abnormalities in the remote (not local) default network connectivity were significantly associated with episodic memory performance in patients. These distance-related connectivity profiles illustrated a dysfunctional pattern in aMCI, which extended our knowledge of this pathological aging process. (C) 2017 Elsevier Inc. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Geriatrics & Gerontology ; Neurosciences |
研究领域[WOS] | Geriatrics & Gerontology ; Neurosciences & Neurology |
关键词[WOS] | DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; POSTERIOR CINGULATE CORTEX ; ONSET ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; MEMORY-TASK ; SYSTEMS NEUROSCIENCE ; EPISODIC RETRIEVAL ; BRAIN ACTIVITY |
收录类别 | SCI ; SSCI |
语种 | 英语 |
WOS记录号 | WOS:000405463300015 |
源URL | [http://ir.psych.ac.cn/handle/311026/21638] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
作者单位 | 1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 4.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Lifespan Connectome & Behav Team, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yi-Wen,Zhao, Zhi-Lian,Qi, Zhigang,et al. Local-to-remote cortical connectivity in amnestic mild cognitive impairment[J]. NEUROBIOLOGY OF AGING,2017,56(0):138-149. |
APA | Zhang, Yi-Wen.,Zhao, Zhi-Lian.,Qi, Zhigang.,Hu, Yang.,Wang, Yin-Shan.,...&Zuo, Xi-Nian.(2017).Local-to-remote cortical connectivity in amnestic mild cognitive impairment.NEUROBIOLOGY OF AGING,56(0),138-149. |
MLA | Zhang, Yi-Wen,et al."Local-to-remote cortical connectivity in amnestic mild cognitive impairment".NEUROBIOLOGY OF AGING 56.0(2017):138-149. |
入库方式: OAI收割
来源:心理研究所
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