The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair
文献类型：期刊论文
| 作者 | Cui Y ; Liu Y ; Cui Y ; Jing XB ; Zhang PBA ; Chen XS |
| 刊名 | acta biomaterialia
 |
| 出版日期 | 2009 |
| 卷号 | 5期号:7页码:2680-2692 |
| 关键词 | IN-VITRO PART I COMPOSITES TISSUE POLY(L-LACTIDE) POLYMERIZATION OSTEOGENESIS ATTACHMENT PARTICLES CERAMICS |
| ISSN号 | 1742-7061 |
| 通讯作者 | zhang pba |
| 中文摘要 | nanohydroxyapatite (op-ha) surface-modified with l-lactic acid oligomer (lac oligomer) was prepared by lac oligomer grafted onto the hydroxyapatite (ha) surface. the nanocomposite of op-ha/plga with different op-ha contents of 5, 10, 20 and 40 wt.% in the composite was fabricated into three-dimensional scaffolds by the melt-molding and particulate leaching methods. plga and the nanocomposite of ha/plga with 10 wt.% of ungrafted hydroxyapatite were used as the controls. the scaffolds were highly porous with evenly distributed and interconnected pore structures, and the porosity was around 90%. besides the macropores of 100-300 mu m created by the leaching of nacl particles, the micropores (1-50 mu m) in the pore walls increased with increasing content of op-ha in the composites of op-ha/plga. the op-ha particles could disperse more uniformly than those of pure ha in plga matrix. the 20 wt.% op-ha/plga sample exhibited the maximum mechanical strength, including bending strength (4.14 mpa) and compressive strength (2.31 mpa). the cell viability and the areas of the attached osteoblasts on the films of 10 wt.% op-ha/plga and 20 wt.% op-ha/plga were evidently higher than those on the other composites. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270636900033 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/11837]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Cui Y,Liu Y,Cui Y,et al. The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair[J]. acta biomaterialia,2009,5(7):2680-2692. |
| APA | Cui Y,Liu Y,Cui Y,Jing XB,Zhang PBA,&Chen XS.(2009).The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair.acta biomaterialia,5(7),2680-2692. |
| MLA | Cui Y,et al."The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair".acta biomaterialia 5.7(2009):2680-2692. |
入库方式： OAI收割
来源：长春应用化学研究所
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