Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum
文献类型：期刊论文
| 作者 | Gao, Fei1; Yao, Yuan-Cheng1; Cai, Sheng-Bao1; Zhao, Tian-Rui1; Yang, Xiao-Yan2; Fan, Jian1; Li, Xiao-Nian3; Cao, Jian-Xin1; Cheng, Gui-Guang1 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 118页码:107-111 |
| 关键词 | Epigynum auritum Epigynosides E-G Pregnane glycosides Immunosuppressive |
| 英文摘要 | Phytochemical investigation on the leaves of Epigynum auritum led to the isolation of three novel C-21 pregnane glycosides, epigynosides, E-G (1-3), together with two known pregnane glycosides, epigynosides A (4) and C (5). Their structures were elucidated based on extensive spectroscopic data (MS, IR, ID and 2D NMR) analysis, as well as comparison with the reported data. The immunological activities of the new compounds was evaluated against concanavalin A (Con A)-stimulated proliferation of mice splenocyte in vitro. Compounds 1-3 displayed significant immunosuppressive activities, close to the efficacy of the positive control (dexamethasone) at the concentration of 50 mu M. (C) 2017 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | C-21 STEROIDAL GLYCOSIDES ; CYNANCHUM-OTOPHYLLUM ; INDOLE ALKALOIDS ; VINCA-MAJOR ; ROOTS ; TRANSPLANTATION ; CONSTITUENTS ; FRACTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000399261700018 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51188]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Yunnan Inst Food Safety, Kunming 6505000, Peoples R China 2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 6505000, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Fei,Yao, Yuan-Cheng,Cai, Sheng-Bao,et al. Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum[J]. FITOTERAPIA,2017,118:107-111. |
| APA | Gao, Fei.,Yao, Yuan-Cheng.,Cai, Sheng-Bao.,Zhao, Tian-Rui.,Yang, Xiao-Yan.,...&Cheng, Gui-Guang.(2017).Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum.FITOTERAPIA,118,107-111. |
| MLA | Gao, Fei,et al."Novel immunosuppressive pregnane glycosides from the leaves of Epigynum auritum".FITOTERAPIA 118(2017):107-111. |
入库方式： OAI收割
来源：昆明植物研究所
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