Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oils from Piper Species
文献类型：期刊论文
| 作者 | Xiang, Cai-Peng1; Han, Jia-Xin1; Li, Xing-Cong3; Li, Yun-Hui4; Zhang, Yi4; Chen, Lin1; Qu, Yan6; Hao, Chao-Yun5; Li, Hai-Zhou1; Yang, Chong-Ren1,4,6 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2017-05-10 |
| 卷号 | 65期号:18页码:3702-3710 |
| 关键词 | essential oil Piper P. hispidimervium asaricin acetylcholinesterase inhibitory activity |
| 英文摘要 | The essential oils (EOs) derived from aromatic plants such as Piper species are considered to play a role in alleviating neuronal ailments that are associated with inhibition of acetylcholinesterase (AChE). The chemical compositions of 23 EOs prepared from 16 Piper spp. were analyzed by both gas chromatography with a flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of 76 compounds were identified in the EOs from the leaves and stems of 19 samples, while 30 compounds were detected in the EOs from the fruits of four samples. Sesquiterpenes and phenylpropanoids were found to be rich in these EOs, of which asaricin, caryophyllene, caryophyllene oxide, isospathulenol, (+)-spathulenol, and beta-bisabolene are the major constituents. The EOs from the leaves and stems of Piper austrosinense, P. puberulum, P. flaviflorum, P. betle, and P. hispidimervium showed strong AChE inhibitory activity with IC50 values in the range of 1.51 to 13.9 mg/mL. A thin-layer chromatography (TLC) bioautography assay was employed to identify active compound(s) in the most active EO from P. hispidimervium. The active compound was isolated and identified as asaricin, which gave an IC50 value of 0.44 +/- 0.02 mg/mL against AChE, comparable to galantamine with an IC50 0.15 +/- 0.01 mg/mL. |
| 类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
| 关键词[WOS] | BETA-CARYOPHYLLENE ; ALZHEIMERS-DISEASE ; ADUNCUM L. ; ANTIOXIDANT ACTIVITY ; CONSTITUENTS ; ANTIFUNGAL ; PREVENTION ; FRUITS ; BRAZIL ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000401307700014 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51234]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Ctr Pharmaceut Sci, Fac Life Sci & Technol, Chenggong Campus, Kunming 650500, Peoples R China 2.Yunnan Normal Univ, Sch Life Sci, Kunming 650500, Peoples R China 3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA 4.Yunnan Prov Acad Sci & Technol, Yunnan Engn Res Ctr Ethnopharm, Kunming 650101, Peoples R China 5.Chinese Acad Trop Agr Sci, Haikou 100049, Hainan, Peoples R China 6.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Cai-Peng,Han, Jia-Xin,Li, Xing-Cong,et al. Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oils from Piper Species[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(18):3702-3710. |
| APA | Xiang, Cai-Peng.,Han, Jia-Xin.,Li, Xing-Cong.,Li, Yun-Hui.,Zhang, Yi.,...&Xu, Min.(2017).Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oils from Piper Species.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,65(18),3702-3710. |
| MLA | Xiang, Cai-Peng,et al."Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oils from Piper Species".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.18(2017):3702-3710. |
入库方式： OAI收割
来源：昆明植物研究所
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