Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system
文献类型：期刊论文
| 作者 | Han YD ; Tian HY ; He P ; Chen XS ; Jing XB |
| 刊名 | international journal of pharmaceutics
 |
| 出版日期 | 2009 |
| 卷号 | 378期号:1-2页码:159-166 |
| 关键词 | BOVINE SERUM-ALBUMIN POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES POLY(ETHYLENE GLYCOL) BURST RELEASE TRANSFECTION EFFICIENCY POLYESTER MICROSPHERES PULMONARY DELIVERY PLGA MICROSPHERES ORGANIC-SOLVENTS LIQUID-NITROGEN |
| ISSN号 | 0378-5173 |
| 通讯作者 | chen xs |
| 中文摘要 | insulin has been encapsulated in poly(lactic-co-glycolic acid) (plga) microspheres by solid-in-oil-in-oil (s/o/o) emulsion technique using dmf/corn oil as new solvent pairs. to get better encapsulation efficiency, insulin nanoparticles were prepared by the modified isoelectric point precipitation method so that it had good dispersion in the inner oil phase. the resulting microspheres had drug loading of 10% (w/w), while the encapsulation efficiency could be up to 90-100%. and the insulin release from the microspheres could last for 60 days. microspheres encapsulated original insulin with the same method had lower encapsulation efficiency, and shorter release period. laser scanning confocal microscopy indicated the insulin nanoparticle and original insulin had different distribution in microspheres. the results suggested that using insulin nanoparticle was better than original insulin for microsphere preparation by s/o/o method. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269163600025 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/11855]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han YD,Tian HY,He P,et al. Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system[J]. international journal of pharmaceutics,2009,378(1-2):159-166. |
| APA | Han YD,Tian HY,He P,Chen XS,&Jing XB.(2009).Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system.international journal of pharmaceutics,378(1-2),159-166. |
| MLA | Han YD,et al."Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system".international journal of pharmaceutics 378.1-2(2009):159-166. |
入库方式： OAI收割
来源：长春应用化学研究所
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