Cytotoxic steroidal saponins from Trillium kamtschaticum
文献类型：期刊论文
| 作者 | Qin, Xu-Jie1,3 ; Si, Yong-Ai1,3; Chen, Yu1,3; Liu, Hui1,3,4; Ni, Wei1,3; Yan, Huan1,3; Shu, Tong1,3,4; Ji, Yun-Heng2; Liu, Hai-Yang1,3
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| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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| 出版日期 | 2017-06-01 |
| 卷号 | 27页码:2267-2273 |
| 关键词 | Trillium kamtschaticum Liliaceae Steroidal saponins Cytotoxicity |
| 英文摘要 | Eight new steroidal saponins, trillikamtosides K-R (1-8), along with three known analogues, were isolated from the whole plants of Trillium kamtschaticum. Their structures were unambiguously established by interpretation of spectroscopic data (MS and NMR) and chemical methods. Compound 1 had a rare aglycone featuring a skeleton of 16-oxaandrost-5-en-3-01-17-one, which was reported for the first time. The isolated saponins were tested for cytotoxicities against HCT116 cells, and trillikamtoside R (8) was found to show the most cytotoxic effect with an IC50 value of 4.92 mu M. (C) 2017 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | UNDERGROUND PARTS ; GLYCOSIDES ; OLIGOGLYCOSIDES ; YUNNANENSIS ; SAPOGENINS ; PALL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000402023800003 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/51360]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Xu-Jie,Si, Yong-Ai,Chen, Yu,et al. Cytotoxic steroidal saponins from Trillium kamtschaticum[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27:2267-2273. |
| APA | Qin, Xu-Jie.,Si, Yong-Ai.,Chen, Yu.,Liu, Hui.,Ni, Wei.,...&Liu, Hai-Yang.(2017).Cytotoxic steroidal saponins from Trillium kamtschaticum.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27,2267-2273. |
| MLA | Qin, Xu-Jie,et al."Cytotoxic steroidal saponins from Trillium kamtschaticum".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(2017):2267-2273. |
入库方式： OAI收割
来源：昆明植物研究所
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