Potassium-Lead-Switched G-Quadruplexes: A New Class of DNA Logic Gates
文献类型：期刊论文
| 作者 | Li T ; Wang EK ; Dong SJ |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2009 |
| 卷号 | 131期号:42页码:15082-15083 |
| 关键词 | DEOXYRIBOZYME AUTOMATON APTAMERS COMPUTER CIRCUITS |
| ISSN号 | 0002-7863 |
| 通讯作者 | wang ek |
| 中文摘要 | a cation-driven allosteric g-quadruplex dnazyme (pw17) was utilized to devise a conceptually new class of dna logic gate based on cation-tuned ligand binding and release. k+ favors the binding of hemin to parallel-stranded pw17, thereby promoting the dnazyme activity, whereas pb2+ induces pw17 to undergo a parallel-to-antiparallel conformation transition and thus drives hemin to release from the g-quadruplex, deactivating the dnazyme. such a k+-pb2+ switched g-quadruplex, in fact, functions as a two-input inhibit logic gate. with the introduction of another input edta, this g-quadruplex can be further utilized to construct a reversibly operated implication gate. |
| 收录类别 | ANGEW. CHEM. INT. ED., JACS, ADV. MATER., PRL, NUCLEIC ACIDS RES, NATURE SERIES (IF>10) |
| 语种 | 英语 |
| WOS记录号 | WOS:000271272000004 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/11877]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li T,Wang EK,Dong SJ. Potassium-Lead-Switched G-Quadruplexes: A New Class of DNA Logic Gates[J]. journal of the american chemical society,2009,131(42):15082-15083. |
| APA | Li T,Wang EK,&Dong SJ.(2009).Potassium-Lead-Switched G-Quadruplexes: A New Class of DNA Logic Gates.journal of the american chemical society,131(42),15082-15083. |
| MLA | Li T,et al."Potassium-Lead-Switched G-Quadruplexes: A New Class of DNA Logic Gates".journal of the american chemical society 131.42(2009):15082-15083. |
入库方式： OAI收割
来源：长春应用化学研究所
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