Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)
文献类型：期刊论文
| 作者 | Hu XL ; Chen XS ; Wei JZ ; Liu S ; Jing XB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2009 |
| 卷号 | 9期号:5页码:456-463 |
| 关键词 | RING-OPENING POLYMERIZATION CONTROLLED-RELEASE DRUG-DELIVERY POLY(2-CINNAMOYLETHYL METHACRYLATE) DIBLOCK COPOLYMERS NANOSPHERES ACID) GENE STABILIZATION NANOPARTICLES |
| ISSN号 | 1616-5187 |
| 通讯作者 | jing xb |
| 中文摘要 | a biodegradable amphiphilic block copolymer, peg-b-p(la-co-mac), was used to prepare spherical micelles consisting of a hydrophobic p(la-co-mac) core and a hydrophilic peg shell. to improve their stability, the micelles were crosslinked by radical polymerization of the double bonds in the hydrophobic blocks. the crosslinked micelles had similar sizes and a narrow size distribution compared to their uncrosslinked precursor. the improved stability of the crosslinked micelles was confirmed by measurements of the cmc and a thermodynamic investigation. these micelles can internalize into hela cells in vitro as demonstrated by inverted fluorescence microscopy and clsm. these stabilized nanoscale micelles have potential use in biomedical applications such as drug delivery and disease diagnosis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266456200007 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/12297]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hu XL,Chen XS,Wei JZ,et al. Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)[J]. macromolecular bioscience,2009,9(5):456-463. |
| APA | Hu XL,Chen XS,Wei JZ,Liu S,&Jing XB.(2009).Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate).macromolecular bioscience,9(5),456-463. |
| MLA | Hu XL,et al."Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)".macromolecular bioscience 9.5(2009):456-463. |
入库方式： OAI收割
来源：长春应用化学研究所
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