Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers
文献类型：期刊论文
| 作者 | Shi Q ; Huang YB ; Chen XS ; Wu M ; Sun J ; Jing XB |
| 刊名 | biomaterials
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:28页码:5077-5085 |
| 关键词 | IRON PROTOPORPHYRIN-IX BLOOD-CELL SUBSTITUTES HUMAN SERUM-ALBUMIN CLICK CHEMISTRY DRUG-DELIVERY IN-VIVO METHEMOGLOBIN FORMATION RED-CELL ALIPHATIC POLYESTERS BUILDING-BLOCKS |
| ISSN号 | 0142-9612 |
| 通讯作者 | jing xb |
| 中文摘要 | an artificial oxygen carrier is constructed by conjugating hemoglobin molecules to biodegradable micelles. firstly a series of triblock copolymers (peg-pmpc-pla) in which the middle block contains pendant propargyl groups were synthesized and characterized. after the amphiphilic copolymer was self-assembled into core-shell micelles in aqueous solution, azidized hemoglobin molecules protected by carbon monoxide (co) were conjugated to the micelles via click reaction between the propargyl and azido groups. the conjugation causes an increase of the micelle's mean diameter. maximum conjugation ratio is 250 wt% in the hemoglobin-conjugated micelles (hcms). oxygen-binding ability of the hcms was demonstrated by converting the co-binding state of the hcms into o-2-binding state. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269459900025 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/12301]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi Q,Huang YB,Chen XS,et al. Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers[J]. biomaterials,2009,30(28):5077-5085. |
| APA | Shi Q,Huang YB,Chen XS,Wu M,Sun J,&Jing XB.(2009).Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers.biomaterials,30(28),5077-5085. |
| MLA | Shi Q,et al."Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers".biomaterials 30.28(2009):5077-5085. |
入库方式： OAI收割
来源：长春应用化学研究所
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