Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity
文献类型：期刊论文
| 作者 | Xu XL ; Chen XS ; Wang ZF ; Jing XB |
| 刊名 | european journal of pharmaceutics and biopharmaceutics
 |
| 出版日期 | 2009 |
| 卷号 | 72期号:1页码:18-25 |
| 关键词 | ADVANCED SOLID TUMORS CONTROLLED-RELEASE DRUG-DELIVERY ELECTROSPUN MICE ADRIAMYCIN PHARMACOKINETICS DEGRADATION FORMULATION NANOFIBERS |
| ISSN号 | 0939-6411 |
| 通讯作者 | jing xb |
| 中文摘要 | by means of "emulsion-electrospinning", both hydrophobic and hydrophilic drugs, paclitaxel (ptx) and doxorubicin hydrochloride (dox), were successfully loaded into peg-pla nanofiber mats to realize multi-drug delivery. the release behaviors of both the drugs from the same fiber mats were ascribed to their solubility properties and distribution status in the fibers. due to its high hydrophilicity, dox was easy to diffuse out from the fibers, and its release rate was always faster than that of hydrophobic ptx. moreover, the release rate of ptx was accelerated by dox's release from the same drug-loaded fibers. in vitro cytotoxicity against rat glioma c6 cells indicated that the dual drug combination showed a higher inhibition and apoptosis against c6 cells than a single drug-loaded system, which suggests the promise for multi-drug delivery on combination therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000265777400003 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/12311]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu XL,Chen XS,Wang ZF,et al. Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity[J]. european journal of pharmaceutics and biopharmaceutics,2009,72(1):18-25. |
| APA | Xu XL,Chen XS,Wang ZF,&Jing XB.(2009).Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity.european journal of pharmaceutics and biopharmaceutics,72(1),18-25. |
| MLA | Xu XL,et al."Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity".european journal of pharmaceutics and biopharmaceutics 72.1(2009):18-25. |
入库方式： OAI收割
来源：长春应用化学研究所
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