In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)
文献类型：期刊论文
| 作者 | Zhang PB ; Hong ZK ; Yu T ; Chen XS ; Jing XB |
| 刊名 | biomaterials
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:1页码:58-70 |
| 关键词 | BONE-TISSUE COMPOSITE SCAFFOLDS BIOMATERIAL BEHAVIOR |
| ISSN号 | 0142-9612 |
| 通讯作者 | chen xs |
| 中文摘要 | nanocomposite of hydroxyapatite (hap) surface-grafted with poly(l-lactide) (plla) (g-hap) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. in this paper, a 3-d porous scaffold of g-hap/poly (lactide-co-glycolide) (plga) was fabricated using the solvent casting/particulate leaching method to investigate its applications in bone replacement and tissue engineering. the composite of un-grafted hap/plga and neat plga were used as controls. their in vivo mineralization and osteogenesis were investigated by intramuscular implantation and replacement for repairing radius defects of rabbits. after surface modification, more uniform distribution of g-hap particles but a lower calcium exposure on the surface of g-hap/plga was observed. intramuscular implantation study showed that the scaffold of g-hap/plga was more stable than that of plga, and exhibited similar mineralization and biodegradability to hap/plga at the 12-20 weeks post-surgery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261139100008 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/12325]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang PB,Hong ZK,Yu T,et al. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)[J]. biomaterials,2009,30(1):58-70. |
| APA | Zhang PB,Hong ZK,Yu T,Chen XS,&Jing XB.(2009).In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide).biomaterials,30(1),58-70. |
| MLA | Zhang PB,et al."In vivo mineralization and osteogenesis of nanocomposite scaffold of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)".biomaterials 30.1(2009):58-70. |
入库方式： OAI收割
来源：长春应用化学研究所
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