Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release
文献类型：期刊论文
| 作者 | Zhao CW ; Zhuang XL ; He P ; Xiao CS ; He CL ; Sun JR ; Chen XS ; Jing XB |
| 刊名 | polymer
 |
| 出版日期 | 2009 |
| 卷号 | 50期号:18页码:4308-4316 |
| 关键词 | POLY N-ISOPROPYLACRYLAMIDE POLY(ASPARTIC ACID) POLY(ETHYLENE GLYCOL) COPOLYMER HYDROGELS SENSITIVE HYDROGELS PROTEIN DELIVERY TEMPERATURE GELS ENCAPSULATION NETWORKS |
| ISSN号 | 0032-3861 |
| 通讯作者 | zhuang xl |
| 中文摘要 | novel intelligent hydrogels composed of biodegradable and ph-sensitive poly(l-glutamic acid) (pga) and temperature sensitive poly(n-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (pnh) were synthesized and characterized for controlled release of hydrophilic drug. the influence of ph on the equilibrium swelling ratios of the hydrogels was investigated. a higher pnh content resulted in lower equilibrium swelling ratios. although temperature had little influence on the swelling behaviors of the hydrogels, the changes of optical transmittance of hydrogels as a function of temperature were marked, which showed that the pnh part of hydrogel exhibited hydrophobic property at temperature above the lower critical solution temperature (lcst). the biodegradation rate of the stimuli-sensitive hydrogels in the presence of enzyme was directly proportional to the pga content. lysozyme was chosen as a model drug and loaded into the hydrogels. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272959000004 |
| 公开日期 | 2010-05-27 |
| 源URL | [http://202.98.16.49/handle/322003/12327]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao CW,Zhuang XL,He P,et al. Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release[J]. polymer,2009,50(18):4308-4316. |
| APA | Zhao CW.,Zhuang XL.,He P.,Xiao CS.,He CL.,...&Jing XB.(2009).Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release.polymer,50(18),4308-4316. |
| MLA | Zhao CW,et al."Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release".polymer 50.18(2009):4308-4316. |
入库方式： OAI收割
来源：长春应用化学研究所
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