Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs
文献类型：期刊论文
| 作者 | Fei, Jianjun ; Wen, Xiaoxiao ; Lin, Xiao ; Saijilafu ; Wang, Weihua ; Ren, Olga ; Chen, Xinjian ; Tan, Lili ; Yang, Ke ; Yang, Huilin ; Yang, Lei |
| 刊名 | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 78页码:1155-1163 |
| 关键词 | Nerve repair Magnesium alloys Biodegradation Dorsal root ganglion Biocompatibility |
| ISSN号 | 0928-4931 |
| 通讯作者 | Lin, X (reprint author), Soochow Univ, Room 318 Bldg 1,South Campus,708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China. ; Yang, K (reprint author), Inst Met Sci & Technol, 72 Wenhua Rd, Shenyang 110016, Liaoning Provin, Peoples R China. ; Yang, L (reprint author), Soochow Univ, Room 313 Bldg 1,South Campus,708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China. |
| 中文摘要 | Nerve injury, especially the large-size nerve damage, is a serious problem affecting millions of people. Entubulation of two ends of the injured nerve by using an implantable device, e.g., nerve guidance conduit (NGC), to guide the regeneration of nerve tissue is a promising approach for treating the large-size nerve defect. Magnesium (Mg) and its alloys are biodegradable, conductive, and own good mechanical properties. Mg2+ ion, one of the main degradation products of Mg and its alloys, was reported to promote the proliferation of neural stem cells and their neurite production. Thus, Mg and its alloys are potential materials for fabricating the nerve repair implants, such as NGC or scaffold. However, the compatibility of Mg alloys to cells, especially neurons is not clear. In this work, NZ20 (Mg-2Nd-Zn), ZN20 (Mg-2Zn-Nd) and Mg-10Li magnesium alloys were selected for study, due to the improved mechanical properties of NZ20 and ZN20 alloys and bio-function of Li+ ions from Mg-10Li to nervous system, respectively. The degradation behavior and biocompatibility were studied by in vitro degradation test and cell adhesion assay, respectively. Specifically, the cytocompatibility to dorsal root ganglion (DRG) neurons, RF/6A choroid-retina endothelial cells, and osteoblasts in the cell culture media containing Mg alloy extracts were investigated. The results showed that Mg alloys degraded at different rates in cell culture media and artificial cerebrospinal fluid. The three alloy extracts showed negligible toxic effects on the endothelial cells and osteoblasts at short term (1 day), while NZ20 extract inhibited the proliferation of these two types of cells. The effect of Mg alloy extracts on cell proliferation was also concentration-dependent. For DRG neurons, ZN20 and Mg-10Li alloy extracts showed no neural toxicity compared with control group. The results of the present work show a potential and feasibility of Mg-10Li and ZN20 for nerve repair applications. (C) 2017 Elsevier B.V. All rights reserved. |
| 学科主题 | Materials Science, Biomaterials |
| 收录类别 | SCI |
| 资助信息 | National Basic Research Program of China (973 Program) [2014CB748600]; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD); Jiangsu Innovation and Entrepreneurship Program; National Natural Science Foundation of China [51672184, 81622032, 81501858, 51472279]; Jiangsu Provincial Special Program of Medical Science [BL2012004]; Jiangsu Six Peak of Talents Program [2013-WSW-056] |
| 语种 | 英语 |
| 公开日期 | 2017-08-17 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/78014]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Fei, Jianjun,Wen, Xiaoxiao,Lin, Xiao,et al. Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,78:1155-1163. |
| APA | Fei, Jianjun.,Wen, Xiaoxiao.,Lin, Xiao.,Saijilafu.,Wang, Weihua.,...&Yang, Lei.(2017).Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,78,1155-1163. |
| MLA | Fei, Jianjun,et al."Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 78(2017):1155-1163. |
入库方式： OAI收割
来源：金属研究所
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