Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair
文献类型：期刊论文
| 作者 | Cao, Lei ; Li, Xiaokang ; Zhou, Xiaoshu ; Li, Yong ; Vecchio, Kenneth S. ; Yang, Lina ; Cui, Wei ; Yang, Rui ; Zhu, Yue ; Guo, Zheng ; Zhang, Xing |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-03-22 |
| 卷号 | 9期号:11页码:9862-9870 |
| 关键词 | sea urchin spines lightweight scaffolds open-cell structure mechanical property finite element analysis bone defect repair |
| ISSN号 | 1944-8244 |
| 通讯作者 | Zhang, X (reprint author), Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China. ; Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China. ; Zhu, Y (reprint author), China Med Univ, Hosp 1, Dept Orthoped, Shenyang 110001, Liaoning, Peoples R China. ; Zhang, X (reprint author), Univ Sci & Technol China, Sch Mat Sci, Hefei 230026, Anhui, Peoples R China. |
| 中文摘要 | Sea urchin spines (Heterocentrotus mammillatus), with a hierarchical open-cell structure similar to that of human trabecular bone and superior mechanical property (compressive strength similar to 43.4 MPa) suitable for machining to shape, were explored for potential applications of bone defect repair. Finite element analyses reveal that the compressive stress concentrates along the dense growth rings and dissipates through strut structures of the stereoms, indicating that the exquisite mesostructures play an important role in high strength-to-weight ratios. The fracture strength of magnesium-substituted tricalcium phosphate beta-TCMP) scaffolds produced by hydrothermal conversion of urchin spines is about 9.3 MPa, comparable to that of human trabecular bone. New bone forms along outer surfaces of beta-TCMP scaffolds after implantation in rabbit femoral defects for one month and grows into the majority of the inner open-cell spaces postoperation in three months, showing tight interface between the scaffold and regenerative bone tissue. Fusion of beagle lumbar facet joints using a Ti-6Al-4V cage and beta-TCMP scaffold can be completed within seven months with obvious biodegradation of the beta-TCMP scaffold, which is nearly completely degraded and replaced by newly formed bone ten months after implantation. Thus, sea urchin spines suitable for machining to shape have advantages for production of biodegradable artificial grafts for bone defect repair. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [31300788, 81171773]; National High-Tech R&D Program of China (863 program) [2015AA033702]; Hundred-Talent Program from Chinese Academy of Sciences |
| 语种 | 英语 |
| 公开日期 | 2017-08-17 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/78225]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Cao, Lei,Li, Xiaokang,Zhou, Xiaoshu,et al. Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(11):9862-9870. |
| APA | Cao, Lei.,Li, Xiaokang.,Zhou, Xiaoshu.,Li, Yong.,Vecchio, Kenneth S..,...&Zhang, Xing.(2017).Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair.ACS APPLIED MATERIALS & INTERFACES,9(11),9862-9870. |
| MLA | Cao, Lei,et al."Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair".ACS APPLIED MATERIALS & INTERFACES 9.11(2017):9862-9870. |
入库方式： OAI收割
来源：金属研究所
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