Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study
文献类型：期刊论文
| 作者 | Li, Xiaokang ; Gao, Peng ; Wan, Peng ; Pei, Yifeng ; Shi, Lei ; Fan, Bo ; Shen, Chao ; Xiao, Xin ; Yang, Ke ; Guo, Zheng |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-01-19 |
| 卷号 | 7页码:- |
| ISSN号 | 2045-2322 |
| 通讯作者 | Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthopaed, Xian 710032, Peoples R China. ; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China. |
| 中文摘要 | Titanium and its alloys with various porous structures are one of the most important metals used in orthopaedic implants due to favourable properties as replacement for hard tissues. However, surface modification is critical to improve the osteointegration of titanium and its alloys. In this study, a bioactive magnesium coating was successfully fabricated on porous Ti6Al4V by means of arc ion plating, which was proved with fine grain size and high film/substrate adhesion. The surface composition and morphology were characterized by X-ray diffraction and SEM equipped with energy dispersive spectroscopy. Furthermore, the in vitro study of cytotoxicity and proliferation of MC3T3-E1 cells showed that magnesium coated porous Ti6Al4V had suitable degradation and biocompatibility. Moreover, the in vivo studies including fluorescent labelling, micro-computed tomography analysis scan and Van-Gieson staining of histological sections indicated that magnesium coated porous Ti6Al4V could significantly promote bone regeneration in rabbit femoral condylar defects after implantation for 4 and 8 weeks, and has better osteogenesis and osteointegration than the bare porous Ti6Al4V. Therefore, it is expected that this bioactive magnesium coating on porous Ti6Al4V scaffolds with improved osteointegration and osteogenesis functions can be used for orthopedic applications. |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of Youth Fund [51501223]; National High-tech R & D Program (863Program) [2015AA033702]; Shaanxi Science & Technology Research and Development Program [2015GY158, 2016GY198] |
| 语种 | 英语 |
| 公开日期 | 2017-08-17 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/78335]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Li, Xiaokang,Gao, Peng,Wan, Peng,et al. Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study[J]. SCIENTIFIC REPORTS,2017,7:-. |
| APA | Li, Xiaokang.,Gao, Peng.,Wan, Peng.,Pei, Yifeng.,Shi, Lei.,...&Guo, Zheng.(2017).Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study.SCIENTIFIC REPORTS,7,-. |
| MLA | Li, Xiaokang,et al."Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study".SCIENTIFIC REPORTS 7(2017):-. |
入库方式： OAI收割
来源：金属研究所
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