PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy
文献类型：期刊论文
| 作者 | Liu, Xu ; Zhang, Xing ; Zhu, Mo ; Lin, Guanghui ; Liu, Jian ; Zhou, Zhufa ; Tian, Xin ; Pan, Yue |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-01-11 |
| 卷号 | 9期号:1页码:279-285 |
| 关键词 | Au@Pt nanodendrites computed tomography photothermal therapy radiotherapy synergistic effect |
| ISSN号 | 1944-8244 |
| 通讯作者 | Pan, Y (reprint author), Soochow Univ, Coll Chem Chem Engn & Mat Sci, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China. ; Tian, X (reprint author), Soochow Univ, Sch Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China. ; Tian, X (reprint author), Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China. |
| 中文摘要 | The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a-novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed,cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic. |
| 学科主题 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [51402203, 31300788, 31400862]; Natural Science Foundation of Jiangsu Province for Young Scholars [BK20140326]; China Postdoctoral Science Foundation [2015M571797]; Natural Science Foundation of Jiangsu Higher Education Institutions [14KJB430021]; Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry |
| 语种 | 英语 |
| 公开日期 | 2017-08-17 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/78344]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Xu,Zhang, Xing,Zhu, Mo,et al. PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(1):279-285. |
| APA | Liu, Xu.,Zhang, Xing.,Zhu, Mo.,Lin, Guanghui.,Liu, Jian.,...&Pan, Yue.(2017).PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy.ACS APPLIED MATERIALS & INTERFACES,9(1),279-285. |
| MLA | Liu, Xu,et al."PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy".ACS APPLIED MATERIALS & INTERFACES 9.1(2017):279-285. |
入库方式： OAI收割
来源：金属研究所
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